Department of Nuclear Medicine and Biomedical Research Institute, Pusan National University Hospital, 179 Gudeok-ro, Seo-gu, Busan, 49241, Republic of Korea.
Department of Nuclear Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Republic of Korea.
J Neural Transm (Vienna). 2019 Jun;126(6):723-729. doi: 10.1007/s00702-019-02016-w. Epub 2019 May 17.
Fluctuating body weight is a commonly reported nonmotor feature in patients with Parkinson's disease (PD). We hypothesised that striatal dopamine transporter (DAT) density at the time of diagnosis might play an important role in weight regulation in patients with PD. DAT density was measured from I-FP-CIT single-photon emission computed tomography. Region-of-interest analyses were performed to measure the specific binding of I-FP-CIT to DAT, and the putamen-to-caudate nucleus ratio (PCR) was calculated. Body weight was measured at baseline (W0) and at 48 months (W48). We classified subjects into three groups: weight loss, stable, and weight gain. In final analyses, 163 patients (106 men, 57 women) were included. PCR significantly differed by group in men, but not in women or across all patients. In men, PCR was slightly negatively associated with the percentage change in weight. No such correlation was found across all patients or in women. In univariate and multivariate logistic regression analyses, low PCR was associated with future weight gain in men with PD but not in women. In conclusion, striatal DAT availability at the time of diagnosis could predict subsequent weight change in men with PD.
体重波动是帕金森病（PD）患者常见的非运动症状之一。我们假设在诊断时纹状体多巴胺转运体（DAT）的密度可能在 PD 患者的体重调节中发挥重要作用。DAT 密度通过 I-FP-CIT 单光子发射计算机断层扫描来测量。进行了感兴趣区域分析以测量 I-FP-CIT 与 DAT 的特异性结合，并计算了壳核到尾状核的比率（PCR）。在基线（W0）和 48 个月（W48）时测量体重。我们将受试者分为三组：体重减轻、稳定和体重增加。在最终分析中，纳入了 163 名患者（106 名男性，57 名女性）。在男性中，PCR 按组显著不同，但在女性或所有患者中没有差异。在男性中，PCR 与体重变化的百分比呈轻微负相关。在所有患者或女性中均未发现这种相关性。在单变量和多变量逻辑回归分析中，低 PCR 与 PD 男性未来的体重增加相关，但与女性无关。总之，诊断时纹状体 DAT 的可用性可以预测 PD 男性随后的体重变化。
