Lin Yun-Hsuan, Sun Chi-Chin, Yeung Ling, Yu Yu-Wei, Sun Ming-Hui, Chen Kuan-Jen
Department of Ophthalmology, Chang Gung Memorial Hospital, 222 Mai Chin Road, An Leh District, Keelung, Taiwan.
Department of Chinese Medicine, College of Medicine, Chang Gung University, Kwei-shan, Taoyuan, Taiwan.
Jpn J Ophthalmol. 2019 Jul;63(4):297-303. doi: 10.1007/s10384-019-00670-x. Epub 2019 May 18.
To investigate the incidence, prevalence, and factors related to pterygium in Taiwan.
An ecological study METHODS: We analyzed a random sample of 1 million individuals in Taiwan drawn from the National Health Insurance Database (NHIRD), established in 2005, for the period 2000 to 2011. Patients with pterygium were identified using ICD-9-CM diagnostic codes. The prevalence and annual age- and gender-adjusted incidence of pterygium were calculated for each county in Taiwan. The risk factors including ultraviolet (UV) exposure, outdoor occupation, educational level, and average socioeconomic status of each county of each index year were identified. Univariate and backward elimination multivariate selection by the mixed-effects model were performed to identify significant risk factors related to the incidence of pterygium in Taiwan.
A total of 22,063 individuals with pterygium (10,125 men and 11,938 women) were identified in this study. The prevalence of pterygium was 2.14% in the overall population and 3.48% in the population aged 40 years or older. The occurrence of pterygium was greater in women. In addition, this study demonstrated that UV exposure and low educational level are correlated with the age- and gender-adjusted incidence of pterygium.
Our study is the first to use the NHIRD to determine the prevalence (2.14%) and annual age- and gender-adjusted incidence of pterygium among the general population of Taiwan. The relationship of pterygium with UV exposure and educational level suggests a complex and multifactorial etiology for this disease.
调查台湾翼状胬肉的发病率、患病率及相关因素。
一项生态学研究
我们分析了从2005年建立的国民健康保险数据库（NHIRD）中抽取的100万台湾个体的随机样本，研究时间段为2000年至2011年。使用ICD - 9 - CM诊断编码识别翼状胬肉患者。计算台湾各县翼状胬肉的患病率以及年龄和性别调整后的年发病率。确定各指标年份每个县的危险因素，包括紫外线（UV）暴露、户外职业、教育水平和平均社会经济地位。采用混合效应模型进行单因素和向后消除多因素选择，以确定与台湾翼状胬肉发病率相关的显著危险因素。
本研究共识别出22,063例翼状胬肉患者（男性10,125例，女性11,938例）。翼状胬肉在总体人群中的患病率为2.14%，在40岁及以上人群中为3.48%。女性翼状胬肉的发病率更高。此外，本研究表明紫外线暴露和低教育水平与年龄和性别调整后的翼状胬肉发病率相关。
我们的研究首次使用NHIRD确定台湾普通人群中翼状胬肉的患病率（2.14%）以及年龄和性别调整后的年发病率。翼状胬肉与紫外线暴露和教育水平的关系表明该疾病病因复杂且具有多因素性。
