Molecular Medicine, Research Institute, The Hospital for Sick Children.
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Curr Opin Clin Nutr Metab Care. 2019 Jul;22(4):284-288. doi: 10.1097/MCO.0000000000000569.
To review recent evidence for the role of carbohydrates in the promotion of de novo lipogenesis and lipoprotein secretion from the intestine.
The consumption of diets rich in carbohydrates have been shown to promote elevations in circulating lipids. In particular, the consumption of monosaccharides, such as glucose and fructose, have been shown to induce increases in intestinal de novo lipogenesis, as well as be used as a substrate for the synthesis of triglycerides and lipoprotein export in the form of chylomicrons. Recently, various systematic reviews have analyzed the relative contribution of dietary fructose to intestinal lipogenesis. Although, there remains controversy within the literature, the body of evidence supports lipogenic effects of high fructose diets. In addition, alterations in markers of de novo lipogenesis within the jejunum of patients with insulin resistance may explain the alterations in their postprandial lipid profile.
Recent evidence supports the contribution of dietary carbohydrates to intestinal lipogenesis and lipoprotein secretion; however, further research is required to fully understand the mechanisms underlying this complex process.
综述碳水化合物在促进肠内新生脂肪生成和脂蛋白分泌中的作用的最新证据。
摄入富含碳水化合物的饮食已被证明可促进循环脂质升高。 特别是，摄入单糖（如葡萄糖和果糖）已被证明可诱导肠内新生脂肪生成增加，并被用作合成甘油三酯和乳糜微粒形式的脂蛋白输出的底物。 最近，各种系统评价分析了饮食果糖对肠内脂肪生成的相对贡献。 尽管文献中仍存在争议，但证据表明高果糖饮食具有致脂作用。 此外，胰岛素抵抗患者空肠内新生脂肪生成标志物的改变可能解释了其餐后脂质谱的改变。
最近的证据支持膳食碳水化合物对肠内新生脂肪生成和脂蛋白分泌的贡献； 然而，需要进一步的研究来充分了解这一复杂过程的机制。
