意大利化脓性汗腺炎患者队列中的非酒精性脂肪性肝病患病率：一项多中心回顾性分析。
Nonalcoholic fatty liver disease prevalence in an Italian cohort of patients with hidradenitis suppurativa: A multi-center retrospective analysis.
作者信息
Damiani Giovanni, Leone Sebastiano, Fajgenbaum Kristen, Bragazzi Nicola L, Pacifico Alessia, Conic Rosalynn Rz, Pigatto Paolo Dm, Maiorana Carlo, Poli Pierpaolo, Berti Emilio, Pace Maria C, Malagoli Piergiorgio, Bettoli Vincenzo, Fiore Marco
机构信息
Department of Dermatology, Case Western Reserve University, Cleveland, OH 44195, United States.
Division of Infectious Diseases, "San Giuseppe Moscati" Hospital, Avellino 83100, Italy.
出版信息
World J Hepatol. 2019 Apr 27;11(4):391-401. doi: 10.4254/wjh.v11.i4.391.
BACKGROUND
Nonalcoholic fatty liver disease (NAFLD) includes two distinct conditions, with different histologic features and prognosis: non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). Furthermore, NASH is the more aggressive necro-inflammatory form, which may accumulate fibrosis and result in End stage liver disease (ESLD). NAFLD is also linked to systemic inflammatory conditions such as psoriasis. NAFLD is currently the most common cause of ESLD in Western countries, becoming a serious public health concern. Hidradenitis suppurativa (HS) is a systemic inflammatory/autoinflammatory disease of the terminal follicular epithelium of the apocrine gland with a prevalence of 0.05% to 4.10%. Due to its systemic inflammatory behavior several comorbidities were recently associated, however liver ones were scarcely assessed.
AIM
To evaluate the prevalence and characteristics of NASH/NAFL in HS patients.
METHODS
This retrospective study is a sub-analysis of a larger study carried out in 4 Italian dermatological centers. In this cohort, there were 83 patients: 51 patients with HS only, 20 patients with HS/NAFL and 12 with HS/NASH.
RESULTS
Inflammatory comorbidities were present in 3.9% of HS only patients, 25% of HS/NAFL patients and 58.3% of HS/NASH patients ( 0.001). Similarly, mean Autoinflammatory Disease Damage Index (ADDI) was significantly higher among patients with HS/NASH (5.3 ± 2.2, 0.001) compared to patients with HS/NAFL or HS only (2.8 ± 1.6 and 2.6 ± 1.4 respectively). Furthermore, ADDI correlates with IHS4 in HS, HS/NAFL and HS/NASH. Diabetic patients have higher Hurley score than not diabetic ones. Ultrasound examination was significantly different in the three groups.
CONCLUSION
HS patients displayed a high prevalence of NASH/NAFLD and ultrasound examination should be particularly addressed to patients that display high ADDI scores.
背景
非酒精性脂肪性肝病（NAFLD）包括两种不同的病症，具有不同的组织学特征和预后：非酒精性脂肪肝（NAFL）和非酒精性脂肪性肝炎（NASH）。此外，NASH是更具侵袭性的坏死性炎症形式，可能会积累纤维化并导致终末期肝病（ESLD）。NAFLD还与全身性炎症性疾病如银屑病有关。NAFLD目前是西方国家ESLD最常见的原因，成为一个严重的公共卫生问题。化脓性汗腺炎（HS）是一种顶泌汗腺终末毛囊上皮的全身性炎症/自身炎症性疾病，患病率为0.05%至4.10%。由于其全身性炎症行为，最近发现了几种合并症，然而肝脏方面的合并症很少被评估。
目的
评估HS患者中NASH/NAFL的患病率和特征。
方法
这项回顾性研究是对在4个意大利皮肤科中心进行的一项更大规模研究的子分析。在这个队列中，有83名患者：51名仅患有HS的患者，20名患有HS/NAFL的患者和12名患有HS/NASH的患者。
结果
仅患有HS的患者中3.9%存在炎症性合并症，HS/NAFL患者中25%存在炎症性合并症，HS/NASH患者中58.3%存在炎症性合并症（P<0.001）。同样，与HS/NAFL或仅患有HS的患者（分别为2.8±1.6和2.6±1.4）相比，HS/NASH患者的平均自身炎症性疾病损伤指数（ADDI）显著更高（5.3±2.2，P<0.001）。此外，ADDI与HS、HS/NAFL和HS/NASH中的IHS4相关。糖尿病患者的Hurley评分高于非糖尿病患者。三组的超声检查有显著差异。
结论
HS患者中NASH/NAFLD的患病率较高，对于ADDI评分高的患者应特别进行超声检查。
Zotero 插件