Harbin Institute of Technology, Shenzhen 518055, China.
German Cancer Research Center, 69120 Heidelberg, Germany.
Cells. 2019 May 23;8(5):499. doi: 10.3390/cells8050499.
As a typical biomedical detection task, nuclei detection has been widely used in human health management, disease diagnosis and other fields. However, the task of cell detection in microscopic images is still challenging because the nuclei are commonly small and dense with many overlapping nuclei in the images. In order to detect nuclei, the most important key step is to segment the cell targets accurately. Based on Mask RCNN model, we designed a multi-path dilated residual network, and realized a network structure to segment and detect dense small objects, and effectively solved the problem of information loss of small objects in deep neural network. The experimental results on two typical nuclear segmentation data sets show that our model has better recognition and segmentation capability for dense small targets.
作为一种典型的生物医学检测任务,细胞核检测已经被广泛应用于人类健康管理、疾病诊断等领域。然而,在显微镜图像中的细胞检测任务仍然具有挑战性,因为细胞核通常较小且密集,图像中存在许多重叠的细胞核。为了检测细胞核,最重要的关键步骤是准确地分割细胞目标。基于 Mask RCNN 模型,我们设计了一种多路径扩张残差网络,并实现了一种分割和检测密集小目标的网络结构,有效地解决了小物体在深度神经网络中信息丢失的问题。在两个典型的核分割数据集上的实验结果表明,我们的模型对密集小目标具有更好的识别和分割能力。