普鲁兰多糖的衍生化方法及应用

Derivatization approaches and applications of pullulan.

作者信息

Tiwari Sanjay, Patil Rahul, Dubey Sunil K, Bahadur Pratap

机构信息

Maliba Pharmacy College, UKA Tarsadia University, Gopal-Vidyanagar Campus, Surat 394350, Gujarat, India.

出版信息

Adv Colloid Interface Sci. 2019 Jul;269:296-308. doi: 10.1016/j.cis.2019.04.014. Epub 2019 May 5.

DOI:10.1016/j.cis.2019.04.014

PMID:31128461

Abstract

Pullulan (PUL), a linear exo-polysaccharide, is useful in industries as diverse as food, cosmetics and pharmaceuticals. PUL presents many favorable characteristics, such as renewable origin, biocompatibility, stability, hydrophilic nature, and availability of reactive sites for chemical modification. With an inherent affinity to asialoglycoprotein receptors, PUL can be used for targeted drug delivery to the liver. Besides, these primary properties have been combined with modern synthetic approaches for developing multifunctional biomaterials. This is evident from numerous studies on approaches, such as hydrophobic modification, cross-linking, grafting and transformation as a polyelectrolyte. In this review, we have discussed up-to-date advances on chemical modifications and emerging applications of PUL in targeted theranostics and tissue engineering. Besides, we offer an overview of its applications in food, cosmetics and environment remediation.

摘要

普鲁兰多糖（PUL）是一种线性胞外多糖，在食品、化妆品和制药等多种行业中都有应用。PUL具有许多优良特性，如可再生来源、生物相容性、稳定性、亲水性以及可用于化学修饰的反应位点。由于对去唾液酸糖蛋白受体具有内在亲和力，PUL可用于肝脏的靶向药物递送。此外，这些主要特性已与现代合成方法相结合，用于开发多功能生物材料。这从众多关于疏水改性、交联、接枝和聚电解质转化等方法的研究中可见一斑。在本综述中，我们讨论了PUL在靶向诊疗和组织工程中的化学修饰及新兴应用的最新进展。此外，我们还概述了其在食品、化妆品和环境修复中的应用。