瘦素在情绪障碍和神经退行性疾病中的作用。
Role of Leptin in Mood Disorder and Neurodegenerative Disease.
作者信息
Zou Xiaohan, Zhong Lili, Zhu Cuilin, Zhao Haisheng, Zhao Fangyi, Cui Ranji, Gao Shuohui, Li Bingjin
机构信息
Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun, China.
Department of Gastrointestinal Colorectal Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
出版信息
Front Neurosci. 2019 May 3;13:378. doi: 10.3389/fnins.2019.00378. eCollection 2019.
Abstract
The critical regulatory role of leptin in the neuroendocrine system has been widely reported. Significantly, leptin can improve learning and memory, affect hippocampal synaptic plasticity, exert neuroprotective efficacy and reduce the risk of several neuropsychiatric diseases. In terms of depression, leptin could modulate the levels of neurotransmitters, neurotrophic factors and reverse the dysfunction in the hypothalamic-pituitary-adrenal axis (HPA). At the same time, leptin affects neurological diseases during the regulation of metabolic homeostasis. With regards to neurodegenerative diseases, leptin can affect them via neuroprotection, mainly including Alzheimer's disease and Parkinson's disease. This review will summarize the mechanisms of leptin signaling within the neuroendocrine system with respect to these diseases and discuss the therapeutic potential of leptin.
摘要
瘦素在神经内分泌系统中的关键调节作用已被广泛报道。值得注意的是，瘦素可以改善学习和记忆，影响海马突触可塑性，发挥神经保护作用并降低几种神经精神疾病的风险。在抑郁症方面，瘦素可以调节神经递质、神经营养因子的水平，并逆转下丘脑 - 垂体 - 肾上腺轴（HPA）的功能障碍。同时，瘦素在调节代谢稳态过程中影响神经系统疾病。关于神经退行性疾病，瘦素可通过神经保护作用影响它们，主要包括阿尔茨海默病和帕金森病。本综述将总结瘦素信号在神经内分泌系统中针对这些疾病的作用机制，并讨论瘦素的治疗潜力。
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2
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3
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