尼泊尔东部学龄儿童尿碘浓度过高与甲状腺功能障碍：一个值得关注的问题。
Excess urinary iodine concentration and thyroid dysfunction among school age children of eastern Nepal: a matter of concern.
作者信息
Tamang Man Kumar, Gelal Basanta, Tamang Binaya, Lamsal Madhab, Brodie David, Baral Nirmal
机构信息
Rotary Club of Dharan Ghopa, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.
Department of Biochemistry, B. P. Koirala Institute of Health Sciences, Dharan, Nepal.
出版信息
BMC Res Notes. 2019 May 27;12(1):294. doi: 10.1186/s13104-019-4332-y.
OBJECTIVES
Deficiency as well as excess dietary iodine is associated with several thyroid disorders including Grave's disease and goitre. Previously, cross sectional studies conducted among school children in Nepal showed high prevalence of iodine deficiency. In contrast, recently, few studies have revealed emerging trends of excess urinary iodine concentration in children. This paper, reports excess urinary iodine excretion and thyroid dysfunction among school age children from eastern Nepal.
RESULTS
It was a community based cross sectional study in which we measured urinary iodine excretion levels among school age children at baseline and after educational program. The educational program consisted of audio-visual and pamphlets on thyroid health. We also screened them for thyroid function status by physical examination and measuring serum thyroid hormones. Our results show that 34.4% of the children had excess urinary iodine concentration above the WHO recommended levels. Overall, 3.2% of the children were identified to have thyroid dysfunction. Urinary iodine concentration was significantly different between types of salt used and between salt iodine content categories.
目的
膳食碘缺乏以及碘过量均与包括格雷夫斯病和甲状腺肿在内的多种甲状腺疾病相关。此前，在尼泊尔学童中开展的横断面研究显示碘缺乏患病率很高。相比之下，最近有少数研究揭示了儿童尿碘浓度过高的新趋势。本文报告了尼泊尔东部学龄儿童尿碘排泄过量及甲状腺功能障碍的情况。
结果
这是一项基于社区的横断面研究，我们在基线时以及教育项目实施后测量了学龄儿童的尿碘排泄水平。该教育项目包括有关甲状腺健康的视听资料和宣传册。我们还通过体格检查和测量血清甲状腺激素对他们的甲状腺功能状态进行了筛查。我们的结果显示，34.4%的儿童尿碘浓度超过了世界卫生组织推荐水平。总体而言，3.2%的儿童被确定存在甲状腺功能障碍。所使用盐的类型以及盐碘含量类别之间的尿碘浓度存在显著差异。
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