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ATP6V0d2 mediates leucine-induced mTORC1 activation and polarization of macrophages.

作者信息

Li Pingfei, Deng Xiaofei, Luo Jing, Chen Yufei, Bi Guoyu, Gong Feili, Wei Zhengping, Liu Na, Li Huabin, Laurence Arian, Yang Xiang-Ping

机构信息

Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.

Department of Immunology, School of Basic Medicine, Hubei University of Medicine, Shiyan, 442000, China.

出版信息

Protein Cell. 2019 Aug;10(8):615-619. doi: 10.1007/s13238-019-0636-x.

DOI:10.1007/s13238-019-0636-x
PMID:31134526
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6626592/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/819d/6626592/32099e192228/13238_2019_636_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/819d/6626592/e7df89126e06/13238_2019_636_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/819d/6626592/32099e192228/13238_2019_636_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/819d/6626592/e7df89126e06/13238_2019_636_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/819d/6626592/32099e192228/13238_2019_636_Fig2_HTML.jpg

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本文引用的文献

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The macrophage-specific V-ATPase subunit ATP6V0D2 restricts inflammasome activation and bacterial infection by facilitating autophagosome-lysosome fusion.巨噬细胞特异性 V-ATPase 亚基 ATP6V0D2 通过促进自噬体-溶酶体融合来限制炎症小体的激活和细菌感染。
Autophagy. 2019 Jun;15(6):960-975. doi: 10.1080/15548627.2019.1569916. Epub 2019 Jan 29.
2
Lactate inhibits ATP6V0d2 expression in tumor-associated macrophages to promote HIF-2α-mediated tumor progression.乳酸抑制肿瘤相关巨噬细胞中 ATP6V0d2 的表达,从而促进 HIF-2α 介导的肿瘤进展。
J Clin Invest. 2019 Feb 1;129(2):631-646. doi: 10.1172/JCI123027. Epub 2019 Jan 7.
3
RNA 测序和蛋白质组学分析揭示了 MPTP 在树鼩(Tupaia belangeri chinensis)慢性胃黏膜损伤中的作用。
Sci Rep. 2024 Jan 2;14(1):74. doi: 10.1038/s41598-023-50820-y.
4
Acid external and internal environment exchange the tissue immune gene expression compared to the mouse macrophage polarization model.酸性内外环境交换组织免疫基因表达与小鼠巨噬细胞极化模型比较。
Front Immunol. 2022 Sep 26;13:1012078. doi: 10.3389/fimmu.2022.1012078. eCollection 2022.
5
ATP6V0d2 Suppresses Alveoli Macrophage Alternative Polarization and Allergic Asthma via Degradation of PU.1.ATP6V0d2通过降解PU.1抑制肺泡巨噬细胞的替代性极化和过敏性哮喘。
Allergy Asthma Immunol Res. 2021 May;13(3):479-497. doi: 10.4168/aair.2021.13.3.479.
KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1.
KICSTOR将GATOR1招募至溶酶体,对于营养物质调节mTORC1而言是必需的。
Nature. 2017 Mar 16;543(7645):438-442. doi: 10.1038/nature21423. Epub 2017 Feb 15.
4
Tissue-Resident Macrophage Ontogeny and Homeostasis.组织驻留巨噬细胞的发生和稳态。
Immunity. 2016 Mar 15;44(3):439-449. doi: 10.1016/j.immuni.2016.02.024.
5
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway.CASTOR蛋白是mTORC1信号通路的精氨酸传感器。
Cell. 2016 Mar 24;165(1):153-164. doi: 10.1016/j.cell.2016.02.035. Epub 2016 Mar 10.
6
The cytotoxic T cell proteome and its shaping by the kinase mTOR.细胞毒性T细胞蛋白质组及其由激酶mTOR塑造的过程。
Nat Immunol. 2016 Jan;17(1):104-12. doi: 10.1038/ni.3314. Epub 2015 Nov 9.
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Nutrient-sensing mechanisms and pathways.营养感知机制与途径。
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Regulation of mTORC1 by the Rag GTPases is necessary for neonatal autophagy and survival.雷帕霉素靶蛋白复合物 1(mTORC1)的 Rag GTPases 调控对于新生儿自噬和存活是必需的。
Nature. 2013 Jan 31;493(7434):679-83. doi: 10.1038/nature11745. Epub 2012 Dec 23.