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本文引用的文献

1
Dose-dependent response of FSH, flushes and urinary calcium to oestrogen.促卵泡激素、潮热及尿钙对雌激素的剂量依赖性反应。
Maturitas. 1982 Dec;4(4):285-90. doi: 10.1016/0378-5122(82)90060-3.
2
Unchanged biochemical indices of bone turnover despite fluctuations in 1,25-dihydroxyvitamin D during the menstrual cycle.
Acta Endocrinol (Copenh). 1983 Mar;102(3):476-80. doi: 10.1530/acta.0.1020476.
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Estrogen replacement therapy by transdermal estradiol administration.
Am J Obstet Gynecol. 1983 Jul 1;146(5):533-40. doi: 10.1016/0002-9378(83)90796-2.
4
Oestrone sulphate in plasma from postmenopausal women and the effects of oestrogen and androgen therapy.绝经后女性血浆中的硫酸雌酮以及雌激素和雄激素治疗的效果。
Clin Endocrinol (Oxf). 1980 Nov;13(5):461-71. doi: 10.1111/j.1365-2265.1980.tb03412.x.
5
Biological effects of various doses of conjugated equine estrogens in postmenopausal women.不同剂量结合马雌激素对绝经后女性的生物学效应。
J Clin Endocrinol Metab. 1980 Sep;51(3):620-5. doi: 10.1210/jcem-51-3-620.
6
Early effects of ethinyloestradiol and norethisterone treatment in post-menopausal women on bone resorption and calcium regulating hormones.炔雌醇和炔诺酮治疗对绝经后妇女骨吸收及钙调节激素的早期影响。
Clin Sci (Lond). 1985 Sep;69(3):265-71. doi: 10.1042/cs0690265.
7
Estrogens and endometrial cancer in a retirement community.退休社区中的雌激素与子宫内膜癌
N Engl J Med. 1976 Jun 3;294(23):1262-7. doi: 10.1056/NEJM197606032942304.

绝经后女性症状、垂体及骨骼对经皮雌激素的剂量依赖性反应。

Dose dependent response of symptoms, pituitary, and bone to transdermal oestrogen in postmenopausal women.

作者信息

Selby P L, Peacock M

出版信息

Br Med J (Clin Res Ed). 1986 Nov 22;293(6558):1337-9. doi: 10.1136/bmj.293.6558.1337.

DOI:10.1136/bmj.293.6558.1337
PMID:3098341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1342052/
Abstract

The effect of the plasma oestradiol concentration on climacteric symptoms, gonadotrophin release, and bone resorption was studied in three groups of postmenopausal women given 0.025 mg, 0.05 mg, or 0.1 mg transdermal oestradiol daily. There was a dose related reduction in symptoms, plasma follicle stimulating hormone concentration, and urinary calcium and hydroxyproline excretion. The relation of the response to plasma oestradiol values was similar for each variable with an initial large reduction and little change in response to increases in the plasma oestradiol concentration above 150 pmol/l (41 pg/ml). Hormone replacement therapy producing an effect equivalent to higher oestradiol concentrations is likely to increase the risk of side effects without conferring any additional benefit.

摘要

研究了三组每日接受0.025毫克、0.05毫克或0.1毫克经皮雌二醇的绝经后妇女，血浆雌二醇浓度对更年期症状、促性腺激素释放及骨吸收的影响。症状、血浆卵泡刺激素浓度以及尿钙和羟脯氨酸排泄均呈剂量相关性降低。每个变量对血浆雌二醇值的反应关系相似，最初大幅降低，而当血浆雌二醇浓度高于150皮摩尔/升（41皮克/毫升）时，反应变化不大。产生等同于更高雌二醇浓度效果的激素替代疗法可能会增加副作用风险，且无任何额外益处。