绝经后女性症状、垂体及骨骼对经皮雌激素的剂量依赖性反应。
Dose dependent response of symptoms, pituitary, and bone to transdermal oestrogen in postmenopausal women.
作者信息
Selby P L, Peacock M
出版信息
Br Med J (Clin Res Ed). 1986 Nov 22;293(6558):1337-9. doi: 10.1136/bmj.293.6558.1337.
Abstract
The effect of the plasma oestradiol concentration on climacteric symptoms, gonadotrophin release, and bone resorption was studied in three groups of postmenopausal women given 0.025 mg, 0.05 mg, or 0.1 mg transdermal oestradiol daily. There was a dose related reduction in symptoms, plasma follicle stimulating hormone concentration, and urinary calcium and hydroxyproline excretion. The relation of the response to plasma oestradiol values was similar for each variable with an initial large reduction and little change in response to increases in the plasma oestradiol concentration above 150 pmol/l (41 pg/ml). Hormone replacement therapy producing an effect equivalent to higher oestradiol concentrations is likely to increase the risk of side effects without conferring any additional benefit.
摘要
研究了三组每日接受0.025毫克、0.05毫克或0.1毫克经皮雌二醇的绝经后妇女，血浆雌二醇浓度对更年期症状、促性腺激素释放及骨吸收的影响。症状、血浆卵泡刺激素浓度以及尿钙和羟脯氨酸排泄均呈剂量相关性降低。每个变量对血浆雌二醇值的反应关系相似，最初大幅降低，而当血浆雌二醇浓度高于150皮摩尔/升（41皮克/毫升）时，反应变化不大。产生等同于更高雌二醇浓度效果的激素替代疗法可能会增加副作用风险，且无任何额外益处。
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