Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, University Hospital of the Paracelsus Medical University, Salzburg, Austria.
Research Program for Receptor Biochemistry and Tumor Metabolism, Department of Pediatrics, University Hospital of the Paracelsus Medical University, Salzburg, Austria; Institute of Human Genetics, Helmholtz Zentrum München, Technical University of Munich, Munich, Germany.
Semin Cell Dev Biol. 2020 Feb;98:211-223. doi: 10.1016/j.semcdb.2019.05.025. Epub 2019 Jun 4.
Although we have entered the era of personalized medicine and tailored therapies, drugs that target a large variety of cancers regardless of individual patient differences would be a major advance nonetheless. This review article summarizes current concepts and therapeutic opportunities in the area of targeting aerobic mitochondrial energy metabolism in cancer. Old drugs previously used for diseases other than cancer, such as antibiotics and antidiabetics, have the potential to inhibit the growth of various tumor entities. Many drugs are reported to influence mitochondrial metabolism. However, here we consider only those drugs which predominantly inhibit oxidative phosphorylation.
尽管我们已经进入了个性化医疗和定制疗法的时代，但针对各种癌症的药物，而不论患者个体差异如何，仍然将是一个重大的进步。这篇综述文章总结了靶向癌症有氧线粒体能量代谢的当前概念和治疗机会。以前用于癌症以外疾病的老药物，如抗生素和抗糖尿病药物，有可能抑制各种肿瘤实体的生长。有许多药物被报道会影响线粒体代谢。但是，在这里我们只考虑那些主要抑制氧化磷酸化的药物。
