School of Electrical and Electronic Engineering, The University of Adelaide, Adelaide, Australia
Center for Heart Rhythm Disorders (CHRD), South Australian Health and Medical Research Institute (SAHMRI), University of Adelaide and Royal Adelaide Hospital, Adelaide, Australia.
Eur Respir J. 2019 Jul 25;54(1). doi: 10.1183/13993003.02175-2018. Print 2019 Jul.
Respiratory frequency ( ) predicts in-hospital and short-term mortality in patients with a variety of pathophysiological conditions, but its predictive value for long-term cardiovascular and all-cause mortality in the general population is unknown. Here, we investigated the relationship between mean nocturnal and mortality in community-dwelling older men and women.We measured mean nocturnal during sleep from overnight polysomnography in 2686 men participating in the Osteoporotic Fractures in Men Study (MrOS) Sleep study and 406 women participating in the Study of Osteoporotic Fractures (SOF) to investigate the relationship between mean nocturnal and long-term cardiovascular and all-cause mortality.166 (6.1%) men in the MrOS cohort (8.9±2.6 years' follow-up) and 46 (11.2%) women in the SOF cohort (6.4±1.6 years' follow-up) died from cardiovascular disease. All-cause mortality was 51.2% and 26.1% during 13.7±3.7 and 6.4±1.6 years' follow-up in the MrOS Sleep study and the SOF cohorts, respectively. Multivariable Cox regression analysis adjusted for significant covariates demonstrated that dichotomised at 16 breaths·min was independently associated with cardiovascular mortality (MrOS: hazard ratio (HR) 1.57, 95% CI 1.14-2.15; p=0.005; SOF: HR 2.58, 95% CI 1.41-4.76; p=0.002) and all-cause mortality (MrOS: HR 1.18, 95% CI 1.04-1.32; p=0.007; SOF: HR 1.50, 95% CI 1.02-2.20; p=0.04).In community-dwelling older men and women, polysomnography-derived mean nocturnal ≥16 breaths·min is an independent predictor of long-term cardiovascular and all-cause mortality. Whether nocturnal mean can be used as a risk marker warrants further prospective studies.
呼吸频率（）可预测各种病理生理条件下患者的住院和短期死亡率，但它对普通人群中心血管和全因死亡率的长期预测价值尚不清楚。在这里，我们研究了社区居住的老年男性和女性的夜间平均呼吸频率（）与死亡率之间的关系。我们通过 2686 名参与男性骨质疏松性骨折研究（MrOS）睡眠研究的男性和 406 名参与骨质疏松性骨折研究（SOF）的女性的整夜多导睡眠图测量了睡眠期间的夜间平均，并研究了夜间平均与长期心血管和全因死亡率之间的关系。MrOS 队列中 166 名（6.1%）男性（8.9±2.6 年随访）和 SOF 队列中 46 名（11.2%）女性（6.4±1.6 年随访）死于心血管疾病。在 MrOS 睡眠研究和 SOF 队列中，分别在 13.7±3.7 年和 6.4±1.6 年的随访中，全因死亡率分别为 51.2%和 26.1%。多变量 Cox 回归分析调整了显著协变量后表明，呼吸频率在 16 次/分钟时，与心血管死亡率独立相关（MrOS：风险比（HR）1.57，95%置信区间 1.14-2.15；p=0.005；SOF：HR 2.58，95%置信区间 1.41-4.76；p=0.002）和全因死亡率（MrOS：HR 1.18，95%置信区间 1.04-1.32；p=0.007；SOF：HR 1.50，95%置信区间 1.02-2.20；p=0.04）。在社区居住的老年男性和女性中，多导睡眠图衍生的夜间平均呼吸频率≥16 次/分钟是长期心血管和全因死亡率的独立预测因子。夜间平均是否可以用作风险标志物尚需进一步的前瞻性研究。
