Sariaslani F S, McGee L R, Ovenall D W
Central Research and Development Department, E. I. du Pont de Nemours and Company, Wilmington, Delaware 19898.
Appl Environ Microbiol. 1987 Aug;53(8):1780-4. doi: 10.1128/aem.53.8.1780-1784.1987.
Various species of "Streptomyces," "Aspergillus," "Rhodotorula," "Brevilegnia," "Syncephalastrum," and "Stysanus" were found to transform precocene II to three major metabolites. These major biotransformation products were isolated from a preparative-scale incubation of precocene II with Streptomyces griseus and were conclusively identified as (-)cis- and (+)trans-precocene II-3,4-dihydrodiols and (+)-3-chromenol. 18O2 incorporation studies indicated the involvement of a monooxygenase enzyme system in precocene II transformation by S. griseus. A mechanism is proposed for the formation of (+)-3-chromenol.
人们发现，“链霉菌属”“曲霉属”“红酵母属”“短梗霉属”“共头霉属”和“柱孢霉属”的多种菌种可将早熟素II转化为三种主要代谢产物。这些主要的生物转化产物是通过在制备规模下将早熟素II与灰色链霉菌一起培养而分离得到的，并最终鉴定为（-）顺式和（+）反式早熟素II - 3,4 - 二氢二醇以及（+）-3 - 色原醇。18O2掺入研究表明，在灰色链霉菌对早熟素II的转化过程中，单加氧酶酶系统参与其中。文中提出了（+）-3 - 色原醇的形成机制。
