Bhattacharjee J W, Srivastava B S
Bull World Health Organ. 1979;57(1):123-8.
Adherence of some wild-type and mutant strains of Vibrio cholerae was studied and the relation between adherence, motility, multiplication, and virulence was examined. Vibrios adhered readily to freshly isolated tissue segments of rabbit intestine at 37 degrees C. The number of vibrios adhering was dependent on the concentration of bacteria to which the tissue was exposed. Adherence was markedly reduced by pretreatment with chloramphenicol and also when intestinal tissue was taken from parenterally or orally immunized rabbits. Non-motile or feebly motile strains were unable to adhere. One motile strain was also found to adhere poorly. The adherence of non-motile or poorly adhering strains was not affected by chloramphenicol. Non-motile, poorly adhering, or slow-growing strains behaved as attenuated strains, suggesting the role of motility, adherence, and multiplication in the virulence of V. cholerae.
对一些霍乱弧菌野生型和突变株的黏附情况进行了研究，并考察了黏附、运动性、增殖和毒力之间的关系。霍乱弧菌在37℃时很容易黏附于新鲜分离的兔肠组织段。黏附的弧菌数量取决于组织所接触的细菌浓度。用氯霉素预处理后，以及从经肠道外或口服免疫的兔获取肠组织时，黏附明显减少。不运动或运动能力弱的菌株无法黏附。还发现一株运动菌株黏附性也很差。不运动或黏附性差的菌株的黏附不受氯霉素影响。不运动、黏附性差或生长缓慢的菌株表现为减毒株，提示运动性、黏附性和增殖在霍乱弧菌毒力中的作用。
