Freter R
Infect Immun. 1972 Aug;6(2):134-41. doi: 10.1128/iai.6.2.134-141.1972.
Intestinal antibody (coproantibody) significantly reduced the adsorption of heat-killed Vibrio cholerae to the mucosa of in vivo isolated ileal loops of adult rabbits. This suggests a direct effect of coproantibody on adsorption, which appears to function in addition to the antibacterial mechanism described earlier. When antivibrio serum was administered passively into intestinal loops, it showed a predilection for the intestinal mucosa. In vivo adsorption of vibrios appeared to parallel their viability, i.e., vibrios killed by heat or in the presence of neomycin adsorbed significantly less than live vibrios. In contrast, in vivo adsorption was only slightly affected in the presence of bacteriostatic concentrations of tetracycline. Adsorption of Salmonella senftenberg and V. cholerae to slices of rabbit ileum in Krebs-Ringer solution appeared to involve different mechanisms, in that the former was strongly removed from the intestinal tissues by sodium lauryl sulfate, whereas vibrios were not affected by this agent. Triton X-100 increased the adsorption of vibrios, whereas rabbit bile and changes in pH had no effect.
肠道抗体（粪抗体）显著降低了热灭活霍乱弧菌对成年兔体内分离的回肠肠袢黏膜的吸附。这表明粪抗体对吸附有直接作用，其作用似乎除了前面所述的抗菌机制外还发挥功能。当将抗弧菌血清被动注入肠袢时，它显示出对肠黏膜的偏好。弧菌在体内的吸附似乎与其活力平行，即热灭活或在新霉素存在下的弧菌吸附量明显少于活弧菌。相比之下，在抑菌浓度的四环素存在下，体内吸附仅受到轻微影响。在克雷布斯 - 林格溶液中，肠炎沙门氏菌和霍乱弧菌对兔回肠切片的吸附似乎涉及不同机制，因为前者可被十二烷基硫酸钠从肠道组织中强烈去除，而弧菌不受该试剂影响。曲拉通X - 100增加了弧菌的吸附，而兔胆汁和pH变化则没有影响。
