Ueda-Consolvo Tomoko, Ozaki Hironori, Nakamura Tomoko, Oiwake Toshihiko, Hayashi Atsushi
Department of Ophthalmology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Sugitani 2630, Toyama, 930-0194, Japan.
Graefes Arch Clin Exp Ophthalmol. 2019 Sep;257(9):1841-1846. doi: 10.1007/s00417-019-04385-0. Epub 2019 Jun 6.
We observed cone photoreceptors by using adaptive optics (AO) fundus camera and optical coherence tomography (OCT) in patients with retinitis pigmentosa (RP) and examined the correlations between cone photoreceptors and visual function over 2 years.
Six patients with RP were studied. All patients underwent measurement using best-corrected decimal visual acuity, OCT, a Humphrey Field Analyzer with the 10-2 test grid pattern, and AO. AO images of the foveal center were obtained using an rtx1™ AO fundus camera, and cone counting was performed at 0.5 mm from the foveal center.
AO detected a decrease of cone density over 2 years in RP patients. However, visual acuity, foveal sensitivity, and photoreceptor thickness were not changed over the 2 years.
AO images showed a decrease in the number of foveal cone densities over 2 years in patients with RP. AO may shorten the period required to predict the RP progression rate.
我们使用自适应光学（AO）眼底相机和光学相干断层扫描（OCT）观察视网膜色素变性（RP）患者的视锥光感受器，并在2年时间内研究视锥光感受器与视觉功能之间的相关性。
对6例RP患者进行了研究。所有患者均接受了最佳矫正小数视力、OCT、采用10-2测试网格模式的汉弗莱视野分析仪以及AO测量。使用rtx1™ AO眼底相机获取黄斑中心的AO图像，并在距黄斑中心0.5毫米处进行视锥细胞计数。
AO检测到RP患者在2年时间内视锥细胞密度下降。然而，视力、黄斑敏感度和光感受器厚度在这2年内没有变化。
AO图像显示RP患者在2年时间内黄斑视锥细胞密度数量下降。AO可能会缩短预测RP进展速度所需的时间。
