色素性视网膜炎患者的视力敏感性丧失与受影响年限的相关性。
Correlation between visual sensitivity loss and years affected for eyes with retinitis pigmentosa.
机构信息
Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan.
出版信息
Jpn J Ophthalmol. 2012 May;56(3):224-9. doi: 10.1007/s10384-012-0135-6. Epub 2012 Apr 3.
PURPOSE
To determine the best clinical measures of visual sensitivity for monitoring disease progression in eyes with retinitis pigmentosa (RP).
METHODS
This survey retrospectively studied results from the Humphrey perimetry central 10-2 program for 123 eyes with RP with regard to the correlation between years affected by RP and clinical measures of visual dysfunction, including mean deviation (MD), average sensitivity of 12 test points (CENT12), average sensitivity of 4 central points (CEN4), foveal threshold (FT), and logarithm of the minimum angle of resolution (LogMAR).
RESULTS
All these value correlated more highly with years of symptoms (P < 0.001 for all) than with years since diagnosis. The correlation coefficient with years of symptoms decreased in the order MD, CENT12, CENT4, FT, and LogMAR. The order differed for a subset of 66 eyes with advanced RP having -15 dB or lower MD, and decreased in the order FT, CENT4, LogMAR and CENT12.
CONCLUSION
Progression in eyes with RP could be well assessed by use of the MD of the Humphrey central 10-2 program in general and by use of FT, CENT4, and CENT12 in cases of advanced RP.
目的
确定监测色素性视网膜炎（RP）患者疾病进展的最佳临床视觉敏感性测量方法。
方法
本调查回顾性研究了 123 只 RP 眼的 Humphrey 视野中心 10-2 程序的结果，研究了受 RP 影响的年数与视觉功能障碍的临床测量值（包括平均偏差 MD、12 个测试点的平均敏感度 CENT12、4 个中央点的平均敏感度 CEN4、黄斑阈值 FT 和最小分辨角对数 LogMAR）之间的相关性。
结果
所有这些值与症状持续时间的相关性均高于与诊断后时间的相关性（所有 P < 0.001）。与症状持续时间的相关系数按 MD、CENT12、CENT4、FT 和 LogMAR 的顺序降低。对于一组 66 只 MD 为-15 dB 或更低的晚期 RP 眼，情况有所不同，其顺序为 FT、CENT4、LogMAR 和 CENT12。
结论
一般来说，Humphrey 中心 10-2 程序的 MD 可很好地评估 RP 眼中的进展，而在晚期 RP 中，FT、CENT4 和 CENT12 也可很好地评估进展。
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