Collaborative Mass Spectrometry Innovation Center, Skaggs School of Pharmacy and Pharmaceutical Sciences, San Diego, USA.
Department of Pediatrics, University of California, San Diego, La Jolla, CA, 92037, USA.
BMC Biol. 2019 Jun 12;17(1):47. doi: 10.1186/s12915-019-0660-6.
Use of skin personal care products on a regular basis is nearly ubiquitous, but their effects on molecular and microbial diversity of the skin are unknown. We evaluated the impact of four beauty products (a facial lotion, a moisturizer, a foot powder, and a deodorant) on 11 volunteers over 9 weeks.
Mass spectrometry and 16S rRNA inventories of the skin revealed decreases in chemical as well as in bacterial and archaeal diversity on halting deodorant use. Specific compounds from beauty products used before the study remain detectable with half-lives of 0.5-1.9 weeks. The deodorant and foot powder increased molecular, bacterial, and archaeal diversity, while arm and face lotions had little effect on bacterial and archaeal but increased chemical diversity. Personal care product effects last for weeks and produce highly individualized responses, including alterations in steroid and pheromone levels and in bacterial and archaeal ecosystem structure and dynamics.
These findings may lead to next-generation precision beauty products and therapies for skin disorders.
人们经常使用皮肤个人护理产品，但这些产品对皮肤的分子和微生物多样性的影响尚不清楚。我们评估了四种美容产品（面部乳液、保湿霜、足粉和除臭剂）在 9 周内对 11 名志愿者的影响。
皮肤的质谱和 16S rRNA 目录显示，停止使用除臭剂会降低化学物质以及细菌和古菌的多样性。研究前使用的美容产品中的特定化合物仍可检测到，半衰期为 0.5-1.9 周。除臭剂和足粉增加了分子、细菌和古菌的多样性，而手臂和面部乳液对细菌和古菌几乎没有影响，但增加了化学多样性。个人护理产品的影响持续数周，并产生高度个体化的反应，包括类固醇和信息素水平以及细菌和古菌生态系统结构和动态的改变。
这些发现可能会为皮肤疾病带来下一代的精准美容产品和疗法。
