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Protective activity of geraniol against acetic acid and - induced gastric ulcers in rats.

作者信息

Bhattamisra Subrat Kumar, Yean Yan Vivian Lee, Koh Lee Chin, Hui Kuean Chew, Candasamy Mayuren, Liew Yun Khoon, Sahu Priyadarshi Soumyaranjan

机构信息

Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.

School of Medicine, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.

出版信息

J Tradit Complement Med. 2018 Jul 10;9(3):206-214. doi: 10.1016/j.jtcme.2018.05.001. eCollection 2019 Jul.


DOI:10.1016/j.jtcme.2018.05.001
PMID:31193983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6544613/
Abstract

Geraniol, an active constituent of rose and palmarosa essential oils, possesses several pharmacological properties, including antioxidant, antibacterial and antiulcer activity. Geraniol was therefore investigated for its antiulcer and anti- activity in rats. Ulcers were induced by injecting acetic acid into the sub-serosal layer of the stomach followed by orogastric inoculation of for 7 days. Geraniol (15 and 30 mg/kg), vehicle and a standard drug combination (amoxicillin, 50 mg/kg; clarithromycin, 25 mg/kg and omeprazole, 20 mg/kg) were administered twice daily for 14 days. All the parameters were measured at the end of treatment. The ulcer index was significantly (P < 0.05) lowered in geraniol and standard drug-treated rats as compared to the control group (4.13 ± 0.43). Treatment with geraniol (30 mg/kg) significantly (P < 0.01) increased the gastric pH along with a reduction in total acidity and gastric juice volume. Geraniol significantly (P < 0.05) attenuated the myeloperoxidase activity and augmented the total glutathione level in gastric mucosa. The extent of damage in the stomach was measured using a histopathological score. The score in control, geraniol (30 mg/kg) and standard drugs was 9, 3.5 and 2.0 respectively. In the rapid urease test, treatment with geraniol (30 mg/kg) and the standard drugs produced a 33% and 67% cure respectively from infection. Further, the reduction in bacterial load in the gastric mucosa was confirmed using modified Giemsa staining. Geraniol was observed to exhibit significant antiulcer and anti- activity in a rodent model.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/e2d5b3b230af/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/0e8468b4ef51/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/cb943d588970/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/6440283b6ef1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/e7bec110b71c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/149cfd32e927/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/e2d5b3b230af/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/0e8468b4ef51/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/cb943d588970/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/6440283b6ef1/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/e7bec110b71c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/149cfd32e927/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9c23/6544613/e2d5b3b230af/gr5.jpg

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Protective activity of geraniol against acetic acid and - induced gastric ulcers in rats.

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本文引用的文献

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Curr Gastroenterol Rep. 2016-7

[2]
Preventive Effect of Geraniol on Diethylnitrosamine-Induced Hepatocarcinogenesis in Rats.

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Naunyn Schmiedebergs Arch Pharmacol. 2014-4

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A biochemical study on the gastroprotective effect of andrographolide in rats induced with gastric ulcer.

Indian J Pharm Sci. 2011-9

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Antibacterial activities of liposomal linolenic acids against antibiotic-resistant Helicobacter pylori.

Mol Pharm. 2012-8-6

[10]
Gastroprotective activity of carvacrol on experimentally induced gastric lesions in rodents.

Naunyn Schmiedebergs Arch Pharmacol. 2012-6-28

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