Bhattamisra Subrat Kumar, Yean Yan Vivian Lee, Koh Lee Chin, Hui Kuean Chew, Candasamy Mayuren, Liew Yun Khoon, Sahu Priyadarshi Soumyaranjan
Department of Life Sciences, School of Pharmacy, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
School of Medicine, International Medical University, Bukit Jalil, 57000, Kuala Lumpur, Malaysia.
J Tradit Complement Med. 2018 Jul 10;9(3):206-214. doi: 10.1016/j.jtcme.2018.05.001. eCollection 2019 Jul.
Geraniol, an active constituent of rose and palmarosa essential oils, possesses several pharmacological properties, including antioxidant, antibacterial and antiulcer activity. Geraniol was therefore investigated for its antiulcer and anti- activity in rats. Ulcers were induced by injecting acetic acid into the sub-serosal layer of the stomach followed by orogastric inoculation of for 7 days. Geraniol (15 and 30 mg/kg), vehicle and a standard drug combination (amoxicillin, 50 mg/kg; clarithromycin, 25 mg/kg and omeprazole, 20 mg/kg) were administered twice daily for 14 days. All the parameters were measured at the end of treatment. The ulcer index was significantly (P < 0.05) lowered in geraniol and standard drug-treated rats as compared to the control group (4.13 ± 0.43). Treatment with geraniol (30 mg/kg) significantly (P < 0.01) increased the gastric pH along with a reduction in total acidity and gastric juice volume. Geraniol significantly (P < 0.05) attenuated the myeloperoxidase activity and augmented the total glutathione level in gastric mucosa. The extent of damage in the stomach was measured using a histopathological score. The score in control, geraniol (30 mg/kg) and standard drugs was 9, 3.5 and 2.0 respectively. In the rapid urease test, treatment with geraniol (30 mg/kg) and the standard drugs produced a 33% and 67% cure respectively from infection. Further, the reduction in bacterial load in the gastric mucosa was confirmed using modified Giemsa staining. Geraniol was observed to exhibit significant antiulcer and anti- activity in a rodent model.
J Tradit Complement Med. 2018-7-10
J Ethnopharmacol. 2015-12-4
Nihon Yakurigaku Zasshi. 2001-10
J Gastroenterol Hepatol. 1998-11
Aliment Pharmacol Ther. 1999-3
Front Microbiol. 2022-8-5
Molecules. 2022-5-26
Curr Gastroenterol Rep. 2016-7
Yonago Acta Med. 2016-3
Korean J Intern Med. 2015-9
World J Gastroenterol. 2014-8-14
Naunyn Schmiedebergs Arch Pharmacol. 2014-4
Naunyn Schmiedebergs Arch Pharmacol. 2012-6-28