Nebe J Barbara, Rebl Henrike, Schlosser Michael, Staehlke Susanne, Gruening Martina, Weltmann Klaus-Dieter, Walschus Uwe, Finke Birgit
Department of Cell Biology, Rostock University Medical Center, Schillingallee 69, 18057 Rostock, Germany.
Department Life, Light & Matter, University of Rostock, Albert-Einstein-Str. 25, 18059 Rostock, Germany.
Polymers (Basel). 2019 Jun 5;11(6):1004. doi: 10.3390/polym11061004.
Biomaterials should be bioactive in stimulating the surrounding tissue to accelerate the ingrowth of permanent implants. Chemical and topographical features of the biomaterial surface affect cell physiology at the interface. A frequently asked question is whether the chemistry or the topography dominates the cell-material interaction. Recently, we demonstrated that a plasma-chemical modification using allylamine as a precursor was able to boost not only cell attachment and cell migration, but also intracellular signaling in vital cells. This microwave plasma process generated a homogenous nanolayer with randomly distributed, positively charged amino groups. In contrast, the surface of the human osteoblast is negatively charged at -15 mV due to its hyaluronan coat. As a consequence, we assumed that positive charges at the material surface-provoking electrostatic interaction forces-are attractive for the first cell encounter. This plasma-chemical nanocoating can be used for several biomaterials in orthopedic and dental implantology like titanium, titanium alloys, calcium phosphate scaffolds, and polylactide fiber meshes produced by electrospinning. In this regard, we wanted to ascertain whether plasma polymerized allylamine (PPAAm) is also suitable for increasing the attractiveness of a ceramic surface for dental implants using Yttria-stabilized tetragonal zirconia.
生物材料应具有生物活性，以刺激周围组织，加速永久性植入物的向内生长。生物材料表面的化学和拓扑特征会影响界面处的细胞生理。一个常见的问题是，化学因素还是拓扑因素在细胞与材料的相互作用中起主导作用。最近，我们证明了以烯丙胺为前驱体的等离子体化学修饰不仅能够促进细胞附着和细胞迁移，还能促进活细胞内的信号传导。这种微波等离子体过程产生了一个具有随机分布的带正电荷氨基的均匀纳米层。相比之下，由于其透明质酸涂层，人类成骨细胞表面带负电荷，为 -15 mV。因此，我们推测材料表面的正电荷引发的静电相互作用力对细胞初次接触具有吸引力。这种等离子体化学纳米涂层可用于骨科和牙科植入领域的多种生物材料，如钛、钛合金、磷酸钙支架以及通过静电纺丝制备的聚乳酸纤维网。在这方面，我们想确定等离子体聚合烯丙胺（PPAAm）是否也适用于提高氧化钇稳定四方氧化锆陶瓷表面对牙科植入物的吸引力。
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