School of Mathematics and Statistics, Changchun University of Technology, Changchun, China.
Department of Statistics, The Chinese University of Hong Kong, Shatin, Hong Kong.
Stat Med. 2019 Sep 10;38(20):3703-3718. doi: 10.1002/sim.8137. Epub 2019 Jun 13.
Variable selection is a crucial issue in model building and it has received considerable attention in the literature of survival analysis. However, available approaches in this direction have mainly focused on time-to-event data with right censoring. Moreover, a majority of existing variable selection procedures for survival models are developed in a frequentist framework. In this article, we consider additive hazards model in the presence of current status data. We propose a Bayesian adaptive least absolute shrinkage and selection operator procedure to conduct a simultaneous variable selection and parameter estimation. Efficient Markov chain Monte Carlo methods are developed to implement posterior sampling and inference. The empirical performance of the proposed method is demonstrated by simulation studies. An application to a study on the risk factors of heart failure disease for type 2 diabetes patients is presented.
变量选择是模型构建中的一个关键问题,在生存分析文献中受到了相当多的关注。然而,这方面的可用方法主要集中在带有右删失的事件时间数据上。此外,大多数现有的生存模型变量选择程序都是在频率主义框架下开发的。本文考虑了当前状态数据存在下的加性风险模型。我们提出了一种贝叶斯自适应最小绝对收缩和选择算子程序,以进行同时的变量选择和参数估计。开发了有效的马尔可夫链蒙特卡罗方法来实现后验抽样和推断。通过模拟研究证明了所提出方法的经验性能。还介绍了一个应用于 2 型糖尿病患者心力衰竭疾病风险因素研究的实例。