Department of Orthopaedics, Shaoxing People's Hospital, Zhejiang University School of Medicine, Shaoxing, 312000, Zhejiang, China.
Department of Orthopaedics, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Inflammation. 2019 Oct;42(5):1754-1766. doi: 10.1007/s10753-019-01037-7.
Osteoarthritis (OA), which is characterized as a common degenerative joint disease, is presently the most prevalent chronic degenerative joint disease. Accumulating evidence has shown a biological function for Garcinol in a variety of diseases; however, whether it could be used to treat OA remains unclear. In this study, we explored the protective effects of garcinol on the progression of OA and explored the underlying mechanism. In vitro, garcinol reduced the expression of pro-inflammatory cytokines, such as IL-6 and tumor necrosis factor alpha (TNF-α). It also decreased the expression of inducible nitric oxide synthase (iNOS), as well as cyclooxygenase-2 (COX-2). Furthermore, garcinol inhibited the expression of thrombospondin motifs 5(ADAMTS5) and metalloproteinase (MMPs), both of which regulate extracellular matrix degradation. These changes could be attributed to garcinol-related suppression of the IL-1β-induced NF-κB signaling pathway. Moreover, we investigated the protective effects of garcinol on the surgical destabilization of the medial meniscus (DMM) of the mouse, an in vivo model of OA. Taken together, our data suggest garcinol as a potential future agent for the treatment of OA.
骨关节炎（OA）是一种常见的退行性关节疾病，目前是最常见的慢性退行性关节疾病。越来越多的证据表明，Garcinol 在多种疾病中具有生物学功能；然而，它是否可用于治疗 OA 尚不清楚。在这项研究中，我们探讨了 Garcinol 对 OA 进展的保护作用，并探讨了其潜在的机制。在体外，Garcinol 降低了促炎细胞因子（如 IL-6 和肿瘤坏死因子α（TNF-α））的表达。它还降低了诱导型一氧化氮合酶（iNOS）和环氧化酶-2（COX-2）的表达。此外，Garcinol 抑制了血小板反应蛋白基序 5（ADAMTS5）和基质金属蛋白酶（MMPs）的表达，这两者都调节细胞外基质的降解。这些变化可能归因于 Garcinol 对 IL-1β 诱导的 NF-κB 信号通路的抑制作用。此外，我们研究了 Garcinol 对内侧半月板手术不稳定（DMM）的保护作用，这是一种 OA 的体内模型。综上所述，我们的数据表明 Garcinol 是治疗 OA 的一种有潜力的未来药物。
