Stamp Lisa K, Chapman Peter, Frampton Christopher, Duffull Stephen B, Drake Jill, Zhang Yuqing, Neogi Tuhina
Department of Medicine, University of Otago, Christchurch.
Department of Rheumatology, Immunology and Allergy, Christchurch Hospital.
Rheumatology (Oxford). 2020 Sep 1;59(9):2374-2380. doi: 10.1093/rheumatology/kez606.
Cherry concentrate has been suggested to reduce serum urate (SU) and gout flares. The aims of this study were to determine the magnitude of the effect of tart cherry concentrate on SU in people with gout, the most effective dose of tart cherry concentrate for lowering SU, and adverse effects.
Fifty people with gout and SU > 0.36 mmol/l were recruited. Half were on allopurinol and half were on no urate-lowering therapy. Participants were randomized to receive tart cherry juice concentrate: placebo, 7.5 ml, 15 ml, 22.5 ml or 30 ml twice daily for 28 days. Blood samples were taken at baseline, then at 1, 3 and 5 h post cherry and then on days 1, 3, 7, 14, 21 and 28. The area under the curve for SU was calculated over the 28-day study period.
Cherry concentrate dose had no significant effect on reduction in SU area under the curve, urine urate excretion, change in urinary anthocyanin between day 0 and day 28, or frequency of gout flares over the 28-day study period (P = 0.76). There were 24 reported adverse events, with only one (hyperglycaemia) considered possibly to be related to cherry concentrate. Allopurinol use did not modify the effect of cherry on SU or urine urate excretion.
Tart cherry concentrate had no effect on SU or urine urate excretion. If there is an effect of cherry concentrate on gout flares over a longer time period, it is not likely to be mediated by reduction in SU.
Australian New Zealand Clinical Trials Registry (ANZCTR), https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=368887, ANZCTR 12615000741583).
有研究表明樱桃浓缩汁可降低血清尿酸（SU）水平并减少痛风发作。本研究旨在确定酸樱桃浓缩汁对痛风患者血清尿酸水平的影响程度、降低血清尿酸的最有效剂量以及不良反应。
招募了50名痛风患者且血清尿酸水平>0.36 mmol/L。其中一半患者正在服用别嘌醇，另一半未接受降尿酸治疗。参与者被随机分为接受酸樱桃浓缩汁：安慰剂、7.5 ml、15 ml、22.5 ml或30 ml，每日两次，共28天。在基线时采集血样，然后在饮用樱桃汁后1、3和5小时采集，随后在第1、3、7、14、21和28天采集。在28天的研究期间计算血清尿酸的曲线下面积。
樱桃浓缩汁剂量对曲线下血清尿酸降低幅度、尿尿酸排泄、第0天至第28天尿花青素变化或28天研究期间痛风发作频率均无显著影响（P = 0.76）。共报告了24起不良事件，其中只有1起（高血糖）可能与樱桃浓缩汁有关。使用别嘌醇并未改变樱桃对血清尿酸或尿尿酸排泄的影响。
酸樱桃浓缩汁对血清尿酸或尿尿酸排泄没有影响。如果樱桃浓缩汁在更长时间内对痛风发作有影响，这种影响不太可能是通过降低血清尿酸来介导的。
澳大利亚新西兰临床试验注册中心（ANZCTR），https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=368887，ANZCTR 12615000741583）
