中国南方猪群中 SARS-CoV 感染的再现。
The re-emerging of SADS-CoV infection in pig herds in Southern China.
机构信息
College of Animal Science, South China Agricultural University, Guangzhou, China.
Key Laboratory of Animal Health Aquaculture and Environmental Control, Guangzhou, China.
出版信息
Transbound Emerg Dis. 2019 Sep;66(5):2180-2183. doi: 10.1111/tbed.13270. Epub 2019 Jul 10.
A new highly virulent swine acute diarrhoea syndrome coronavirus (SADS-CoV) emerged in Guangdong province in 2017 followed by fatal diarrhoea that involved the death of 24,693 piglets. And yet from May 2017 to January 2019, there were no new SADS cases arising in pig herds in Guangdong. In this study, we reported the recent diarrhoea outbreak of SADS-CoV in Southern China on February 2019. Intestinal samples collected from diarrhoeal piglets were detected for common swine virus and confirmed that SADS-CoV was responsible for the diarrhoea case. Meanwhile, serological investigation of sows' sera implied that SADS-CoV has existed in the farm and PEDV antibody may not directly contribute to the amplification of SADS-CoV. Homology and phylogenetic analysis of the whole genome showed that the re-emerging SADS-CoV strain shared high sequence identities with existing SADS-CoV strains and all strains clustered together in Alpha coronavirus. All in all, the report herein emphasized the re-emerging of SADS-CoV and highlights continuous monitoring for this virus.
2017 年，一种新型高致病性猪急性腹泻综合征冠状病毒（SADS-CoV）在中国广东省出现，随后发生了致命性腹泻，导致 24693 头仔猪死亡。然而，从 2017 年 5 月到 2019 年 1 月，广东省的猪群中没有出现新的 SADS 病例。在本研究中，我们报告了 2019 年 2 月中国南方最近发生的 SADS-CoV 腹泻疫情。从腹泻仔猪采集的肠道样本检测了常见的猪病毒，并证实 SADS-CoV 是导致腹泻的原因。同时，对母猪血清的血清学调查表明，SADS-CoV 已经存在于农场中，PEDV 抗体可能不会直接导致 SADS-CoV 的扩增。全基因组的同源性和系统发育分析表明，新出现的 SADS-CoV 株与现有的 SADS-CoV 株具有很高的序列同一性，所有株都聚集在 Alpha 冠状病毒中。总之，本报告强调了 SADS-CoV 的再次出现，并强调了对该病毒的持续监测。
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