Wang Jiao, Li Jianbo, Ren Jie
Institute of Nano and Biopolymeric Materials, Department of Polymeric Materials, Shanghai Key Laboratory for R&D and Application of Metalic Functional Materials, Key Laboratory of Advanced Civil Engineering Materials, Ministry of Education, School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai 201804, China.
Materials (Basel). 2019 Jun 18;12(12):1959. doi: 10.3390/ma12121959.
In this study, a series of poly(lactic-co-glycolic acid) (PLGA) microspheres with different particle sizes for arterial embolization surgery were prepared. The polydopamine (PDA) and polydopamine/polyethyleneimine (PDA/PEI) were respectively coated on the PLGA microspheres as shells, in order to improve the hydrophilicity and dispersibility of PLGA embolization microspheres. After modification, with the introduction of PDA and PEI, many hydrophilic hydroxyl and amine groups appeared on the surface of the PLGA@PDA and PLGA@PDA/PEI microspheres. SEM images showed the morphologies, sizes, and changes of the as-prepared microspheres. Meanwhile, the XPS and FT-IR spectra demonstrated the successful modification of the PDA and PEI. Water contact angles (WCAs) of the PLGA@PDA and PLGA@PDA/PEI microspheres became smaller, indicating a certain improvement in surface hydrophilicity. In addition, the results of in vitro cytotoxicity showed that modification had little effect on the biosafety of the microspheres. The modified PLGA microspheres suggest a promising prospective application in biomedical field, as the modified microspheres can reduce difficulties in embolization surgery.
在本研究中，制备了一系列用于动脉栓塞手术的不同粒径的聚乳酸-乙醇酸共聚物（PLGA）微球。分别用聚多巴胺（PDA）和聚多巴胺/聚乙烯亚胺（PDA/PEI）作为壳层包覆在PLGA微球上，以提高PLGA栓塞微球的亲水性和分散性。改性后，随着PDA和PEI的引入，PLGA@PDA和PLGA@PDA/PEI微球表面出现了许多亲水性羟基和胺基。扫描电子显微镜（SEM）图像显示了所制备微球的形态、尺寸和变化。同时，X射线光电子能谱（XPS）和傅里叶变换红外光谱（FT-IR）证明了PDA和PEI的成功改性。PLGA@PDA和PLGA@PDA/PEI微球的水接触角（WCA）变小，表明表面亲水性有一定改善。此外，体外细胞毒性结果表明改性对微球的生物安全性影响较小。改性后的PLGA微球在生物医学领域具有广阔的应用前景，因为改性微球可以减少栓塞手术中的困难。
