Geelong Centre for Emerging Infectious Diseases, Geelong, Victoria, Australia.
Deakin University, School of Medicine, Geelong, Victoria, Australia.
Sci Rep. 2019 Jun 20;9(1):8906. doi: 10.1038/s41598-019-45445-z.
Human parechovirus type 3 (HPeV3) can cause severe sepsis-like illness in young infants and may be associated with long term neurodevelopmental delay later in childhood. We investigated the molecular epidemiology of HPeV infection in thirty three infants requiring hospitalization before, during and after the peak of the 2017/18 HPeV epidemic wave in Australia. During the peak of the epidemic, all cases were infected with an HPeV3, while before and after the peak, HPeV1 was the predominant type detected. The predominant HPeV3 was the recombinant HPeV3 also detected in the 2013/14 and 2015/16 Australian epidemics. Sepsis-like or meningitis-like symptoms were only reported in cases infected with the recombinant HPeV3. Phylogenetic analysis of the recombinant HPeV3 revealed that the virus continued to evolve, also between the Australian outbreaks, thus indicating continued circulation, despite not being detected and reported in Australia or elsewhere in between epidemic waves. The recombinant HPeV3 continued to show a remarkable stability in its capsid amino acid sequence, further strengthening our previous argument for development of a vaccine or immunotherapeutics to reduce the severity of HPeV3 outbreaks due to this virus.
人类肠道病毒 3 型（HPeV3）可导致婴幼儿发生严重类似脓毒症的疾病，并且可能与儿童后期的长期神经发育迟缓有关。我们调查了 33 名在澳大利亚 2017/18 年 HPeV 流行高峰之前、期间和之后需要住院治疗的婴儿的 HPeV 感染的分子流行病学。在流行高峰期间，所有病例均感染了 HPeV3，而在高峰之前和之后，检测到的主要类型是 HPeV1。主要的 HPeV3 是与 2013/14 年和 2015/16 年澳大利亚流行的 HPeV3 重组型相同。仅在感染重组 HPeV3 的病例中报告了类似脓毒症或脑膜炎的症状。对重组 HPeV3 的系统进化分析表明，该病毒仍在继续进化，即使在流行高峰期之间，在澳大利亚或其他地方也没有检测到和报告这种病毒，该病毒也仍在继续传播。重组 HPeV3 继续在其衣壳氨基酸序列中显示出显著的稳定性，这进一步加强了我们之前的观点，即开发疫苗或免疫疗法来减轻由该病毒引起的 HPeV3 爆发的严重程度。
