Division of Cardiothoracic and Vascular Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave., Wuhan, 430030, China.
Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, China.
Cell Mol Life Sci. 2019 Oct;76(19):3711-3722. doi: 10.1007/s00018-019-03161-x. Epub 2019 Jun 19.
Studies over the past decades have elucidated the critical role of autophagy in human health and diseases. Although the processes of autophagy in the cytoplasm have been well studied, the posttranscriptional and epigenetic regulation mechanisms of autophagy are still poorly understood. Protein methylation, including histone methylation and non-histone protein methylation, is the most important type of posttranscriptional and epigenetic modification. Recent studies have shown that protein methylation is associated with effects on autophagosome formation, autophagy-related protein expression, and signaling pathway activation, but the details are still unclear. Thus, it is important to summarize the current status and discuss the future directions of research on protein methylation in the context of autophagy.
过去几十年的研究阐明了自噬在人类健康和疾病中的关键作用。尽管细胞质中的自噬过程已经得到了很好的研究，但自噬的转录后和表观遗传调控机制仍知之甚少。蛋白质甲基化包括组蛋白甲基化和非组蛋白蛋白质甲基化，是最重要的转录后和表观遗传修饰类型。最近的研究表明，蛋白质甲基化与自噬体形成、自噬相关蛋白表达和信号通路激活有关，但具体细节尚不清楚。因此，总结蛋白质甲基化在自噬背景下的研究现状并探讨未来的研究方向非常重要。
