Department of Biochemistry and Molecular Biology, Complutense University of Madrid, 28040, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Department of Biochemistry and Molecular Biology, Complutense University of Madrid, 28040, Madrid, Spain; Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029, Madrid, Spain.
Mol Immunol. 2019 Aug;112:291-304. doi: 10.1016/j.molimm.2019.06.007. Epub 2019 Jun 19.
Soluble defense collagens form a group of secreted proteins that are primarily involved in host defense. All defense collagens contain a globular recognition domain contiguous to a collagen-like triple helical domain. They are oligomeric proteins, assembled in multiples of three subunits due to their collagen domains. Members of this group include collectins such as surfactant protein A and D (SP-A, SP-D), and mannan-binding lectin; C1q, the first component of the complement system; adiponectin; and ficolins. All are secreted to tissue cavities or serum. Soluble defense collagens are specialized to respond to infection, triggering the initiation of the complement cascade and/or enhancing phagocytosis of pathogens by macrophages. However, once inflammation is established, C1q, collectins, ficolins, or adiponectin can influence macrophage responses, thereby contributing to resolve the inflammation. In addition, some members of this group of proteins (SP-A, C1q, and adiponectin) modulate tissue-repair functions of macrophages. This review will focus on the molecular mechanisms by which these proteins efficiently defend against immune threats and contribute to tissue repair.
可溶性防御胶原形成一组分泌蛋白，主要参与宿主防御。所有防御胶原都包含一个球形识别结构域，与胶原样三螺旋结构域连续。它们是寡聚蛋白，由于其胶原结构域，以三的倍数组装。该组的成员包括表面活性剂蛋白 A 和 D（SP-A、SP-D）和甘露聚糖结合凝集素；补体系统的第一成分 C1q；脂联素；和纤维胶凝蛋白。所有这些都分泌到组织腔或血清中。可溶性防御胶原专门用于应对感染，触发补体级联反应的启动和/或增强巨噬细胞对病原体的吞噬作用。然而，一旦炎症建立，C1q、凝集素、纤维胶凝蛋白或脂联素可以影响巨噬细胞的反应，从而有助于缓解炎症。此外，该蛋白组的一些成员（SP-A、C1q 和脂联素）调节巨噬细胞的组织修复功能。这篇综述将重点介绍这些蛋白有效抵御免疫威胁和促进组织修复的分子机制。
