Shen Nayu, Chen Zhao, Wang Siyu, Zhang Mingqi, Jia Yujie, Zhang Xinyu, Xiao Yirong, Tang Zizhong, Li Qingfeng, Yuan Ming, Bu Tongliang
College of Life Sciences, Sichuan Agricultural University, Ya'an, China.
Ya'an People's Hospital, Ya'an, China.
PeerJ. 2025 Aug 13;13:e19827. doi: 10.7717/peerj.19827. eCollection 2025.
Medicinal plant endophytic fungi hold significant potential for producing natural antioxidants, as they thrive in environments rich in bioactive antioxidant compounds.
This study focuses on , an endophytic fungus isolated from (Sam.) Juzep., to explore the antioxidant activity associated with the ethyl acetate extract (CGE) and to explore the underlying mechanisms.
The results indicated that CGE treatment enhances the stress resistance in , stimulates the antioxidant protection mechanisms of , and exhibits strong antioxidant activity . RNA-seq analysis showed that CGE regulates Fatty acid degradation, glutathione metabolism, longevity regulating pathway-multiple species and MAPK signaling pathway in . This study offers an important reference to the utilization of CGE as an antioxidant in the food and medical sectors, while also establishing a theoretical framework for utilizing the as a natural antioxidant source.
药用植物内生真菌在产生天然抗氧化剂方面具有巨大潜力，因为它们在富含生物活性抗氧化化合物的环境中生长。
本研究聚焦于从（萨姆）朱泽普分离出的一种内生真菌，以探索与乙酸乙酯提取物（CGE）相关的抗氧化活性，并探究其潜在机制。
结果表明，CGE处理增强了（某种植物）的抗逆性，刺激了（该植物）的抗氧化保护机制，并表现出强大的抗氧化活性。RNA测序分析表明，CGE在（该植物）中调节脂肪酸降解、谷胱甘肽代谢、长寿调节途径——多种物种以及丝裂原活化蛋白激酶信号通路。本研究为将CGE用作食品和医疗领域的抗氧化剂提供了重要参考，同时也为将（该植物）用作天然抗氧化剂来源建立了理论框架。
