Department of Psychology, University of Southern Mississippi, Hattiesburg, MS, USA; Child Study Center, Yale School of Medicine, New Haven, CT, USA.
Child Study Center, Yale School of Medicine, New Haven, CT, USA.
Psychiatry Res. 2019 Aug;278:248-257. doi: 10.1016/j.psychres.2019.06.021. Epub 2019 Jun 17.
A primary goal of this study was to examine the impact of an Integrated Brain, Body, and Social (IBBS) intervention (multi-faceted treatment consisting of computerized cognitive training, physical exercise, and behavior management) on ERPs of attentional control (P3 & N2) in children with ADHD. The secondary goal was to test the differences between children with and without ADHD on ERP and Go/No-Go behavioral measures. A total of twenty-nine participants (M age = 7.14 years; 52% male; 41.4% white) recruited from the IBBS efficacy study comparing IBBS to Treatment-As-Usual (TAU) completed a Go/No-Go task before and after treatment as brain activity was recorded using EEG. Thirty-four matched healthy controls (HC) completed the same EEG procedures at a single time point. Following treatment, the Go P3 latency was significantly earlier for the IBBS group relative to the TAU group. No treatment effects were found on any behavioral measures. Prior to treatment, there was a significant difference between the ADHD group and HC group for the N2 difference wave. Children with ADHD also showed slower reaction times on behavioral measures. Although this pilot study did not reveal robust treatment effects, it suggests that IBBS may prevent the worsening of attentional systems in the brain and larger studies are needed for replication purposes.
本研究的主要目标是考察综合脑、身体和社会（IBBS）干预（包括计算机认知训练、体育锻炼和行为管理的多方面治疗）对 ADHD 儿童注意力控制（P3 和 N2）ERP 的影响。次要目标是测试 ERP 和 Go/No-Go 行为测量中 ADHD 儿童和无 ADHD 儿童之间的差异。共有 29 名参与者（M 年龄=7.14 岁；52%为男性；41.4%为白人）从 IBBS 疗效研究中招募，该研究比较了 IBBS 与常规治疗（TAU），在治疗前后使用 EEG 记录大脑活动时完成了 Go/No-Go 任务。34 名匹配的健康对照组（HC）在单个时间点完成了相同的 EEG 程序。治疗后，IBBS 组的 Go P3 潜伏期明显早于 TAU 组。在任何行为测量上均未发现治疗效果。在治疗前，ADHD 组和 HC 组之间的 N2 差异波存在显著差异。ADHD 儿童在行为测量上的反应时间也较慢。尽管这项初步研究未显示出明显的治疗效果，但它表明 IBBS 可能预防大脑注意力系统的恶化，需要进行更大规模的研究以进行复制。
