Sipos Attila Gergely, Kozma Bence, Poka Robert, Larson Kindra, Takacs Peter
Department of Obstetrics and Gynecology, University of Debrecen Faculty of Medicine, 98 Nagyerdei krt, 4032, Debrecen, Hungary.
Department of Obstetrics and Gynecology, Division of Female Pelvic Medicine and Reconstructive Surgery, Eastern Virginia Medical School, 825 Fairfax Avenue, Suite 526, Norfolk, Virginia, 23507-2007.
Lasers Surg Med. 2019 Dec;51(10):882-886. doi: 10.1002/lsm.23126. Epub 2019 Jun 25.
To assess the improvement on pelvic floor distress (PFD)-related urogenital symptoms using validated questionnaires after intravaginal CO laser treatment.
STUDY DESIGN/MATERIALS AND METHODS: Forty postmenopausal women with genitourinary symptoms of menopause (GSM) were enrolled into this prospective cohort study and underwent vaginal laser treatment using MonaLisa Touch® fractional CO laser system. Patients received three vaginal laser treatments with 360° probe 4 weeks apart. A three-component Pelvic Floor Distress Inventory (PFDI-20) validated questionnaire was filled out by each patient before each session and 4 weeks after the final treatment. Wilcoxon rank sum test was used to compare the before and after treatment scores.
Pelvic Organ Prolapse Distress Inventory (POPDI-6) scores were not significantly different after the first treatment compared with baseline (mean ± standard deviation [SD], 21 ± 18 vs. 17 ± 15, P = 0.44). However, each subsequent treatment resulted in further, statistically significant improvement in symptom scores (14 ± 15, P = 0.03 and 13 ± 13, P = 0.01, after the second and third treatments, respectively). Similarly, Urinary Distress Inventory (UDI-6) scores were not significantly different after the first laser treatment (mean ± SD, 36 ± 25 vs. 29 ± 23, P = 0.36). After the second and third treatments there were significant improvement in the standardized scores (24 ± 20, P = 0.03 and 22 ± 21, P = 0.01). Colorectal-Anal Distress Inventory (CRADI-8) scores did not change significantly after three laser treatments.
Three sessions of microablative fractional CO vaginal laser treatment significantly improves patient reported urinary and pelvic organ prolapse symptoms. Lasers Surg. Med. © 2019 The Authors. Lasers in Surgery and Medicine Published by Wiley Periodicals, Inc.
使用经过验证的问卷评估经阴道CO2激光治疗后盆底功能障碍（PFD）相关泌尿生殖系统症状的改善情况。
研究设计/材料与方法：40名有绝经后泌尿生殖系统症状（GSM）的绝经后女性被纳入这项前瞻性队列研究，并使用蒙娜丽莎触摸®分次CO2激光系统接受阴道激光治疗。患者接受三次阴道激光治疗，每次使用360°探头，间隔4周。每位患者在每次治疗前及最后一次治疗后4周填写一份经过验证的包含三个部分的盆底功能障碍量表（PFDI-20）问卷。采用Wilcoxon秩和检验比较治疗前后的得分。
与基线相比，第一次治疗后盆腔器官脱垂困扰量表（POPDI-6）得分无显著差异（均值±标准差[SD]，21±18 vs. 17±15，P = 0.44）。然而，随后的每次治疗均使症状得分在统计学上有进一步显著改善（第二次和第三次治疗后分别为14±15，P = 0.03和13±13，P = 0.01）。同样，第一次激光治疗后泌尿困扰量表（UDI-6）得分无显著差异（均值±SD，36±25 vs. 29±23，P = 0.36）。第二次和第三次治疗后标准化得分有显著改善（24±20，P = 0.03和22±21，P = 0.01）。三次激光治疗后结直肠-肛门困扰量表（CRADI-8）得分无显著变化。
三次微剥脱分次CO2阴道激光治疗可显著改善患者报告的泌尿及盆腔器官脱垂症状。激光外科杂志。©2019作者。激光手术与医学由威利期刊公司出版。
