Rio de Janeiro State University, Rio de Janeiro, Brazil.
Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
Clin Transplant. 2019 Aug;33(8):e13654. doi: 10.1111/ctr.13654. Epub 2019 Jul 11.
Obesity is associated with increased risk of cardiovascular disease (CVD). Body mass index (BMI) is the most used parameter for obesity screening. However, the evaluation of CVD risk in overweight individuals should include the assessment of body fat distribution and body composition. Renal transplant recipients (RTR) have a high CVD risk and frequently present weight gain and loss of lean mass. The aim of this study was to evaluate body fat distribution and body composition in overweight RTR. This cross-sectional study was conducted with 86 RTR and 86 hypertensive individuals (comparison group, CG) presenting BMI 25-35 Kg/m and 45-70 years. Anthropometric evaluation included BMI, waist circumference, waist-to-height ratio, and a body shape index. Body composition was evaluated with bioelectrical impedance analysis (BIA). Glomerular filtration rate was estimated (eGFR) by CKD-EPI equation. RTR group (RTRG) and CG presented similar age and BMI. RTRG when compared to CG presented lower percentage of women and eGFR; higher central adiposity; and lower values of reactance, intracellular water, body cell mass and phase angle, more consistently observed in women. This study suggests that overweight RTR present higher abdominal adiposity and impairment in BIA parameters that are sensitive indicators of impaired membrane integrity, water distribution, and body cell mass.
肥胖与心血管疾病（CVD）风险增加相关。身体质量指数（BMI）是最常用于肥胖筛查的参数。然而，超重个体的 CVD 风险评估应包括体脂肪分布和身体成分的评估。肾移植受者（RTR）具有较高的 CVD 风险，并且经常出现体重增加和瘦体重减少。本研究旨在评估超重 RTR 的体脂肪分布和身体成分。这是一项横断面研究，共纳入 86 名 RTR 和 86 名高血压个体（对照组，CG），BMI 为 25-35kg/m2，年龄为 45-70 岁。体格评估包括 BMI、腰围、腰高比和身体形状指数。身体成分采用生物电阻抗分析（BIA）进行评估。通过 CKD-EPI 方程估算肾小球滤过率（eGFR）。RTR 组（RTRG）和 CG 的年龄和 BMI 相似。与 CG 相比，RTRG 女性比例较低，eGFR 较低；中心性肥胖程度较高；以及反应电抗、细胞内液、体细胞质量和相位角等 BIA 参数值较低，这些参数在女性中更为明显。本研究表明，超重的 RTR 存在更高的腹部脂肪堆积和 BIA 参数受损，这些参数是膜完整性、水分分布和体细胞质量受损的敏感指标。
