University of Strasbourg, CNRS, Immunology, Immunopathology and Therapeutic Chemistry, UPR 3572, 67000, Strasbourg, France.
Graduate School of Human and Environmental Studies, Kyoto University, Sakyo-ku, Kyoto, 606-8501, Japan.
Angew Chem Int Ed Engl. 2019 Dec 9;58(50):17918-17929. doi: 10.1002/anie.201905997. Epub 2019 Aug 27.
Nanodiamond(ND)-based technologies are flourishing in a wide variety of fields spanning from electronics and optics to biomedicine. NDs are considered a family of nanomaterials with an sp carbon core and a variety of sizes, shapes, and surfaces. They show interesting physicochemical properties such as hardness, stiffness, and chemical stability. Additionally, they can undergo ad-hoc core and surface functionalization, which tailors them for the desired applications. Noteworthy, the properties of NDs and their surface chemistry are highly dependent on the synthetic method used to prepare them. In this Minireview, we describe the preparation of NDs from the materials-chemistry viewpoint. The different methodologies of synthesis, purification, and surface functionalization as well as biomedical applications are critically discussed. New synthetic approaches as well as limits and obstacles of NDs are presented and analyzed.
基于纳米金刚石（ND）的技术正在电子、光学和生物医药等多个领域蓬勃发展。ND 被认为是一类具有 sp 碳核和各种尺寸、形状和表面的纳米材料。它们具有硬度、刚度和化学稳定性等有趣的物理化学性质。此外，它们可以进行特定的核心和表面功能化，从而根据需要的应用进行定制。值得注意的是，ND 的性质及其表面化学性质高度依赖于用于制备它们的合成方法。在这篇综述中，我们从材料化学的角度描述了 ND 的制备。对不同的合成方法、纯化方法和表面功能化方法以及生物医学应用进行了批判性讨论。介绍和分析了新的合成方法以及 ND 的局限性和障碍。
