Institute of Life Science, Swansea University Medical School, Singleton Park, Swansea, SA2 8PP, UK.
Curr Opin Insect Sci. 2019 Aug;34:1-6. doi: 10.1016/j.cois.2019.02.001. Epub 2019 Feb 12.
RNA interference (RNAi) is a transformative technology with great potential to control, study or even protect insects and acarines through the knockdown of target gene expression. RNAi offers unprecedented levels of control, but fundamental to its successful deployment is the need to deliver 'trigger' RNA in an appropriate fashion giving due consideration to potential barriers of RNAi efficiency, safety, and the intended purpose of the knockdown. This short review focusses on recent innovations in RNAi delivery that are designed for, or could be adapted for use with, insect and acarine pests of medical or veterinary importance.
RNA 干扰 (RNAi) 是一项具有变革性的技术，具有通过靶基因表达的敲低来控制、研究甚至保护昆虫和螨虫的巨大潜力。RNAi 提供了前所未有的控制水平，但要成功部署它，关键是需要以适当的方式递送“触发”RNA，同时充分考虑 RNAi 效率、安全性和敲低的预期目的等潜在障碍。本文简要综述了 RNA 递送的最新创新，这些创新是专门为具有医学或兽医学重要性的昆虫和螨虫害虫设计的，或者可以加以改编用于这些害虫。
