Neuroscience Program, Smith College, Northampton, MA.
Department of Biology, University of Washington, Seattle WA.
Yale J Biol Med. 2019 Jun 27;92(2):259-270. eCollection 2019 Jun.
Circadian disruption has been linked to markers for poor health outcomes in humans and animal models. What is it about circadian disruption that is problematic? One hypothesis is that phase resetting of the circadian system, which occurs in response to changes in environmental timing cues, leads to internal desynchrony within the organism. Internal desynchrony is understood as acute changes in phase relationships between biological rhythms from different cell groups, tissues, or organs within the body. Do we have strong evidence for internal desynchrony associated with or caused by circadian clock resetting? Here we review the literature, highlighting several key studies from measures of gene expression in laboratory rodents. We conclude that current evidence offers strong support for the premise that some protocols for light-induced resetting are associated with internal desynchrony. It is important to continue research to test whether internal desynchrony is necessary and/or sufficient for negative health impact of circadian disruption.
昼夜节律紊乱与人类和动物模型中不良健康结果的标志物有关。昼夜节律紊乱有什么问题？一种假设是，昼夜节律系统的相位重置会对环境定时线索的变化做出反应，从而导致生物体内部的不同步。内部不同步被理解为体内不同细胞群、组织或器官的生物节律之间相位关系的急性变化。我们是否有强有力的证据表明与昼夜节律钟重置相关或由其引起的内部不同步？在这里，我们回顾了文献，重点介绍了来自实验室啮齿动物基因表达测量的几项关键研究。我们的结论是，目前的证据有力地支持了这样一个前提，即一些光诱导重置的方案与内部不同步有关。继续研究以测试内部不同步是否是昼夜节律紊乱对健康产生负面影响的必要和/或充分条件非常重要。
