Laboratory of Algal, Systems, and Synthetic Biology, Division of Science and Math, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates; Center for Systems Biology and Faculty of Industrial Engineering, Mechanical Engineering and Computer Science, School of Engineering and Natural Sciences, University of Iceland, 101 Reykjavík, Iceland.
Center for Genomics and Systems Biology, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates.
Curr Opin Biotechnol. 2019 Oct;59:157-164. doi: 10.1016/j.copbio.2019.05.013. Epub 2019 Jun 25.
Microalgae have been investigated for the photosynthetic production of natural products with industrial and biomedical applications. Their rapid growth offers an advantage over higher plants, while their complex metabolic capacities allow for the production of various molecules. Despite their potentials, molecular techniques are underdeveloped in microalgae compared to higher plants, fungi, and bacteria. However, recent advances in genome sequencing, strain development, and genome editing technologies, are providing thrust to enhance research on microalgal species that have branched out from several focal model organisms to encompass a great diversity of species. In this review, we highlight the recent, significant advances in microalgal research, with a focus on the development of new resources that can enhance work on model and non-model species.
微藻已被研究用于通过光合作用生产具有工业和生物医学应用的天然产物。它们的快速生长相对于高等植物具有优势,而它们复杂的代谢能力允许生产各种分子。尽管它们具有潜力,但与高等植物、真菌和细菌相比,微藻的分子技术还不够发达。然而,基因组测序、菌株开发和基因组编辑技术的最新进展为增强对从几个焦点模式生物分支出来的微藻物种的研究提供了动力,涵盖了极大的物种多样性。在这篇综述中,我们强调了微藻研究的最新重要进展,重点介绍了可以增强对模型和非模型物种的研究的新资源的开发。