Huang Xinyi, Hong Chaoqun, Peng Yuhui, Yang Shihan, Huang Lisheng, Liu Cantong, Chen Liuyi, Chu Lingyu, Xu Liyan, Xu Yiwei
Department of Clinical Laboratory Medicine, the Cancer Hospital of Shantou University Medical College, Shantou 515041.
Department of Oncological Laboratory Research, the Cancer Hospital of Shantou University Medical College, Shantou 515041.
J Cancer. 2019 Jun 2;10(12):2687-2693. doi: 10.7150/jca.32393. eCollection 2019.
Esophageal squamous cell cancer (ESCC) is one of the leading malignant cancer in the world and especially in China with high incidence and mortality. The exploration of novel serum biomarkers is required for early detection of ESCC. We investigated the diagnostic value of serum insulin like growth factor binding protein 7 (IGFBP7) in ESCC, evaluating its potential to improve the diagnosis of ESCC. The serum samples of 106 patients with ESCC and 107 normal controls were tested by enzyme-linked immunosorbent assay (ELISA). The levels of IGFBP7 in ESCC group were significantly higher than that in normal controls, compared by the Mann-Whitney U test (). Using receiver operating characteristic (ROC) curve, the diagnostic value of serum IGFBP7 was demonstrated. Versus normal group, the area under the ROC curve (AUC) of all ESCC was 0.794 (95%CI: 0.735-0.853) and early-stage ESCC was 0.725 (95%CI: 0.633-0.817). With optimized cutoff value of 2.993 ng/mL, IGFBP7 showed certain diagnostic value with specificity of 90.7%, sensitivities of 40.6% and 32.4% in ESCC and early-stage ESCC, respectively. Considering the correlation between clinical data and IGFBP7, no significant association was found (all ). Thus, we supposed that serum IGFBP7 might be a potential biomarker in the diagnosis of ESCC.
食管鳞状细胞癌（ESCC）是全球尤其是中国主要的恶性肿瘤之一，其发病率和死亡率都很高。早期检测ESCC需要探索新的血清生物标志物。我们研究了血清胰岛素样生长因子结合蛋白7（IGFBP7）在ESCC中的诊断价值，评估其改善ESCC诊断的潜力。采用酶联免疫吸附测定（ELISA）检测了106例ESCC患者和107例正常对照的血清样本。通过Mann-Whitney U检验比较，ESCC组的IGFBP7水平显著高于正常对照组。利用受试者工作特征（ROC）曲线，证明了血清IGFBP7的诊断价值。与正常组相比，所有ESCC的ROC曲线下面积（AUC）为0.794（95%CI：0.735 - 0.853），早期ESCC为0.725（95%CI：0.633 - 0.817）。IGFBP7的最佳临界值为2.993 ng/mL，在ESCC和早期ESCC中分别显示出一定的诊断价值，特异性为90.7%，敏感性分别为40.6%和32.4%。考虑到临床数据与IGFBP7之间的相关性，未发现显著关联（均 ）。因此，我们推测血清IGFBP7可能是ESCC诊断中的一种潜在生物标志物。
