与HIV感染相关的肠道微生物代谢产物。
Gut microbial metabolites associated with HIV infection.
作者信息
Wang Zheng, Qi Qibin
机构信息
Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
出版信息
Future Virol. 2019 May;14(5):335-347. doi: 10.2217/fvl-2019-0002. Epub 2019 May 15.
Abstract
HIV infection has been associated with alterations in gut microbiota and related microbial metabolite production. However, the mechanisms of how these functional microbial metabolites may affect HIV immunopathogenesis and comorbidities, such as cardiovascular disease and other metabolic diseases, remain largely unknown. Here we review the current understanding of gut microbiota and related metabolites in the context of HIV infection. We focus on several bacteria-produced metabolites, including tryptophan catabolites, short-chain fatty acids and trimethylamine-N-oxide (TMAO), and discuss their implications in HIV infection and comorbidities. We also prospect future studies using integrative multiomics approaches to better understand host-microbiota-metabolites interactions in HIV infection, and facilitate integrative medicine utilizing the microbiota in HIV infection.
摘要
HIV感染与肠道微生物群的改变以及相关微生物代谢产物的产生有关。然而，这些功能性微生物代谢产物如何影响HIV免疫发病机制以及合并症（如心血管疾病和其他代谢性疾病）的机制在很大程度上仍不清楚。在此，我们综述了在HIV感染背景下对肠道微生物群及其相关代谢产物的当前认识。我们重点关注几种细菌产生的代谢产物，包括色氨酸分解代谢产物、短链脂肪酸和氧化三甲胺（TMAO），并讨论它们在HIV感染和合并症中的意义。我们还展望了未来使用综合多组学方法进行的研究，以更好地理解HIV感染中宿主-微生物群-代谢产物之间的相互作用，并促进在HIV感染中利用微生物群的整合医学。
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Clin Infect Dis. 2020 Feb 3;70(4):615-627. doi: 10.1093/cid/ciz258.
2
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