Wang Qiao, Liu Zhen-Yu, Zhou Jia
Department of Ultrasound, The First Affiliated Hospital of University of South China, Hengyang, China.
J Int Med Res. 2019 Jul;47(7):2848-2855. doi: 10.1177/0300060519851354. Epub 2019 Jul 5.
Migraine is believed to be a risk factor for cerebrovascular diseases, and previous studies have indicated an association between migraine and cerebral atherosclerosis. Carotid artery intima-media thickness (IMT) is considered to be a biomarker of atherosclerosis pathology. This study aimed to investigate the relationship between carotid IMT and migraine by conducting a meta-analysis.
We searched Web of Science, PubMed, and the Cochrane Library for eligible studies assessing carotid IMT in patients with migraine and controls. Data were extracted independently by two reviewers and analyzed using Review Manager 5.3 software.
The meta-analysis included seven articles with 555 subjects (279 migraine patients, 276 controls). Carotid IMT was significantly greater in patients with migraine compared with controls. However, there were no significant differences in IMT between patients with migraine with aura (MA) and controls, migraine without aura (MO) and controls, and patients with MA and MO.
Patients with migraine have greater carotid IMT than individuals without migraine, suggesting an association between atherosclerosis and migraine. However, further studies with more samples are needed to confirm this finding.
偏头痛被认为是脑血管疾病的一个危险因素，先前的研究表明偏头痛与脑动脉粥样硬化之间存在关联。颈动脉内膜中层厚度（IMT）被视为动脉粥样硬化病理的一个生物标志物。本研究旨在通过进行一项荟萃分析来探究颈动脉IMT与偏头痛之间的关系。
我们在科学网、PubMed和考克兰图书馆中检索了评估偏头痛患者和对照组颈动脉IMT的符合条件的研究。由两名审阅者独立提取数据，并使用Review Manager 5.3软件进行分析。
该荟萃分析纳入了7篇文章，共555名受试者（279名偏头痛患者，276名对照）。与对照组相比，偏头痛患者的颈动脉IMT显著更高。然而，有先兆偏头痛（MA）患者与对照组、无先兆偏头痛（MO）患者与对照组以及MA患者与MO患者之间的IMT并无显著差异。
偏头痛患者的颈动脉IMT高于无偏头痛者，提示动脉粥样硬化与偏头痛之间存在关联。然而，需要更多样本的进一步研究来证实这一发现。
