Meksuriyen D, Cordell G A, Ruangrungsi N, Tantivatana P
Program for Collaborative Research in the Pharmaceutical Sciences, College of Pharmacy, University of Illinois at Chicago 60612.
J Nat Prod. 1987 Nov-Dec;50(6):1118-25. doi: 10.1021/np50054a018.
Examination of Dracaena loureiri, a Thai medicinal plant possessing anti-bacterial activity, has led to the isolation of two new representatives, 1 and 2, of a rare skeleton of homoisoflavans. Proton assignments of the two isolates were aided by extensive 2D-homonuclear chemical shift correlation and nOe difference spectroscopy. Carbon assignments were completed through the utilization of simple and sensitive one-dimensional techniques such as selective population transfer via one-bond (CSCM 1D) and selective polarization transfer via long range coupling (selective INEPT) experiments. Conformational assignments were proposed through nOe difference spectroscopy and have been established by X-ray crystallography. The absolute configuration is proposed based on the octant rule and a biogenetic pathway for this type of homoisoflavan is briefly discussed.
