Mindful Awareness Research Center and Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine, University of California, Los Angeles, California, United States of America.
PLoS One. 2019 Jul 5;14(7):e0219425. doi: 10.1371/journal.pone.0219425. eCollection 2019.
Latino immigrants experience acculturative stress and increased depression risk. Mindfulness meditation improves depressive symptoms, yet the vast majority of research has focused on English speaking populations.
In this randomized clinical trial with 2 parallel treatment groups, adults with moderate levels of perceived stress (n = 76) were recruited from the Los Angeles community from October 2015 to March 2016, stratified into Spanish- (n = 36) and English speaking (n = 40) language groups, and randomized for 6 weeks of treatment with standardized mindful awareness practices (MAPs) or health education (HE). Main outcome measure was depressive symptoms, measured by the Beck Depression Inventory.
Using an intent-to-treat analysis, the primary outcome, depressive symptoms as indexed by the Beck Depression Inventory, showed greater improvement in MAPs vs. HE, with a between-group post-intervention mean difference of -2.2 (95% CI -4.4 - -0.07) and effect size of 0.28; similar effect sizes were found in the the Spanish- (0.29) and English speaking (0.30) groups. MAPs showed significant improvement relative to HE on secondary outcome of mindfulness with between group difference of 10.7 (95% CI4.5-16.9), but not perceived stress.
The comparable efficacy of Spanish and English formats of mindfulness meditation in improving depressive symptoms suggests that this community based intervention may mitigate depression risk in Latino adults who are experiencing social adversity.
ClinicalTrials.gov NCT03545074.
拉丁裔移民经历着文化适应压力和更高的抑郁风险。正念冥想可以改善抑郁症状,但绝大多数研究都集中在英语人群上。
在这项具有 2 个平行治疗组的随机临床试验中,从 2015 年 10 月至 2016 年 3 月,从洛杉矶社区招募了具有中度感知压力的成年人(n=76),分为西班牙语组(n=36)和英语组(n=40),并随机分为 6 周的标准正念意识实践(MAPs)或健康教育(HE)治疗组。主要结局指标是抑郁症状,用贝克抑郁量表评估。
使用意向治疗分析,主要结局指标,即贝克抑郁量表评估的抑郁症状,MAPs 比 HE 有更大的改善,组间干预后平均差异为-2.2(95%置信区间-4.4 至-0.07),效应量为 0.28;在西班牙语组(0.29)和英语组(0.30)中也发现了类似的效应大小。MAPs 在正念的次要结局上显示出相对于 HE 的显著改善,组间差异为 10.7(95%置信区间 4.5-16.9),但在感知压力上没有差异。
西班牙语和英语正念冥想格式在改善抑郁症状方面具有相当的疗效,这表明这种基于社区的干预措施可能会降低经历社会逆境的拉丁裔成年人的抑郁风险。
ClinicalTrials.gov NCT03545074。