The George Washington University School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA.
The George Washington University School of Medicine and Health Sciences, The George Washington University, Washington, District of Columbia, USA; Department of Neurosurgery, The George Washington University, Washington, District of Columbia, USA; Department of Mechanical and Aerospace Engineering, The George Washington University, Washington, District of Columbia, USA.
World Neurosurg. 2019 Oct;130:369-376. doi: 10.1016/j.wneu.2019.06.209. Epub 2019 Jul 5.
Glioblastoma multiforme (GBM) is the most common and aggressive form of brain cancer in adults. GBM carries a dismal prognosis because of its proliferative, invasive, and angiogenic capabilities and because of its ability to downregulate the immune system. Immune-based therapies under investigation for GBM have been unsuccessful in vivo because of this downregulation. Cold atmospheric plasma (CAP) is a high-energy state of matter that can be applied directly or indirectly to tumor tissue to serve as an adjunct to immunotherapy in the treatment of GBM because it upregulates the immune system by the induction of reactive oxygen species. CAP has the potential to improve the efficacy of existing and investigative immunotherapies for GBM.
多形性胶质母细胞瘤（GBM）是成人中最常见和最具侵袭性的脑癌形式。由于其增殖、侵袭和血管生成能力，以及下调免疫系统的能力，GBM 的预后不佳。由于这种下调，正在研究用于 GBM 的基于免疫的疗法在体内都没有成功。冷等离体（CAP）是一种高能物质，可以直接或间接地应用于肿瘤组织，作为免疫疗法治疗 GBM 的辅助手段，因为它通过诱导活性氧来上调免疫系统。CAP 有可能提高现有的和正在研究的用于 GBM 的免疫疗法的疗效。
