Department of Chemistry, University of Sargodha, Sargodha, Pakistan.
Department of Chemistry, Government Post Graduate Taleem ul Islam College, Chenab Nagar, Pakistan.
Phytother Res. 2019 Oct;33(10):2548-2570. doi: 10.1002/ptr.6423. Epub 2019 Jul 9.
The genus Mentha comprises several aromatic species, which are cultivated world-over due to their distinct aroma and commercial value. In addition to traditional food flavoring uses, Mentha are well recognized for their folk medicinal uses, especially to treat cold, fever, and digestive and cardiovascular disorders. A number of biological activities such as antioxidant, antimicrobial, biopesticidal, antitumor, anticancer, antiviral, antiallergic, antiinflammatory, antihypertensive, and urease inhibitory activity have been ascribed to Mentha. The traditional pharmacological attributes of Mentha herbs can be linked to the occurrence of bioactive phytochemicals such as terpenoids, alcohols, rosmarinic acid, and antioxidant phenolics among others. A rich source of bioactives, different species of Mentha, can be explored as a promising candidate for the development of nutra-pharmaceuticals. This review covers the nutritional, phytochemical, and traditional medicinal aspects and multiple biological activities of some commonly available species of Mentha so as to explore their potential applications for nutra-pharmaceutical and cosmo-nutraceutical industry. Detailed chemical profile and pharmaceutical attributes of various Mentha essential oils are also covered. Moreover, based on computational analysis, quantitative chemical component-antioxidant activity relationship model is reviewed to predict and correlate structure-activity relationship of potential bioactives in selected Mentha essential oils leading to discovery and developmenmt of novel natural drugs.
薄荷属包含多个芳香物种，由于其独特的香气和商业价值，在世界各地都有栽培。除了传统的食品调味用途外，薄荷还因其民间药用用途而广为人知，特别是用于治疗感冒、发烧、消化和心血管疾病。薄荷具有多种生物活性，如抗氧化、抗菌、生物农药、抗肿瘤、抗癌、抗病毒、抗变态反应、抗炎、降压和抑制脲酶活性。薄荷草药的传统药理学特性可以与生物活性植物化学物质的发生联系起来，如萜类、醇类、迷迭香酸和抗氧化酚类等。作为生物活性物质的丰富来源，不同种类的薄荷可以被探索作为开发营养药物的有前途的候选物。本综述涵盖了一些常见薄荷属物种的营养、植物化学和传统医学方面以及多种生物学活性，以探索其在营养药物和化妆品营养行业的潜在应用。还涵盖了各种薄荷精油的详细化学概况和药物属性。此外，基于计算分析，还回顾了定量化学成分-抗氧化活性关系模型，以预测和关联选定薄荷精油中潜在生物活性的结构-活性关系，从而发现和开发新型天然药物。
