Palafox N A, Jain L G, Pinano A Z, Gulick T M, Williams R K, Schatz I J
Armer Ishoda Memorial Hospital, Majuro, Marshall Islands.
JAMA. 1988 May 13;259(18):2740-2.
Twenty-four patients with acute ciguatera fish poisoning were treated with intravenous mannitol, and each patient's condition improved dramatically. All exhibited marked lessening of neurologic and muscular dysfunction within minutes of the administration of mannitol. Gastrointestinal symptoms disappeared more slowly. Two patients in coma and one in shock responded within minutes, with full recovery after infusion. Although these observations were empiric and uncontrolled and the mechanism of action of mannitol in this disease is unclear, mannitol should be considered for initial use in patients with significant illness and morbidity from ciguatera fish poisoning.
24例急性雪卡鱼中毒患者接受了静脉注射甘露醇治疗，每位患者的病情均有显著改善。在输注甘露醇后的几分钟内，所有患者的神经和肌肉功能障碍均明显减轻。胃肠道症状消失得较慢。两名昏迷患者和一名休克患者在几分钟内有反应，输注后完全康复。尽管这些观察是经验性的且未设对照，甘露醇在该病中的作用机制尚不清楚，但对于患有严重雪卡鱼中毒疾病和发病的患者，应考虑将甘露醇作为初始治疗用药。
