CMCC-Centro de Matemática, Computação e Cognição, Laboratório do Biología Computacional e Bioinformática-LBCB, Universidade Federal do ABC, Sao Paulo 01023, Brazil.
School of Medicine, Universidad de Cartagena, Cartagena 130001, Colombia.
Mar Drugs. 2020 Oct 1;18(10):504. doi: 10.3390/md18100504.
Ciguatera is a food intoxication caused by the consumption of primarily coral fish; these species exist in large numbers in the seas that surround the Colombian territory. The underreported diagnosis of this clinical entity has been widely highlighted due to multiple factors, such as, among others, ignorance by the primary care practitioner consulted for this condition as well as clinical similarity to secondary gastroenteric symptoms and common food poisonings of bacterial, parasitic or viral etiology. Eventually, it was found that people affected by ciguatoxins had trips to coastal areas hours before the onset of symptoms. Thanks to multiple studies over the years, it has been possible to identify the relation between toxigenic dinoflagellates and seagrasses, as well as its incorporation into the food chain, starting by fish primarily inhabiting reef ecosystems and culminating in the intake of these by humans. Identifying the epidemiological link, its cardinal symptoms and affected systems, such as gastrointestinal, the peripheral nervous system and, fortunately with a low frequency, the cardiovascular system, leads to a purely clinical diagnostic impression without necessitating further complementary studies; in addition, what would also help fight ciguatera poisoning is performing an adequate treatment of the symptoms right from the start, without underestimating or overlooking any associated complications.
雪卡毒素中毒是一种由食用珊瑚鱼引起的食物中毒;这些物种在哥伦比亚周边海域大量存在。由于多种因素,如初级保健医生对这种疾病的认识不足以及与继发性胃肠道症状和常见的细菌性、寄生虫性或病毒性食源性中毒的临床相似性,导致对这种临床实体的诊断报告不足。最终发现,受雪卡毒素影响的人在出现症状前几个小时曾到过沿海地区。多年来的多项研究已经能够确定产毒甲藻与海草之间的关系,以及其进入食物链的过程,从主要栖息在珊瑚礁生态系统中的鱼类开始,最终人类摄入这些鱼类。确定流行病学联系、其主要症状和受影响的系统,如胃肠道、周围神经系统,以及幸运的是频率较低的心血管系统,会导致纯粹的临床诊断印象,而无需进一步进行补充研究;此外,从一开始就对症状进行适当的治疗,不低估或忽视任何相关的并发症,也将有助于对抗雪卡毒素中毒。