Nanfang Hospital, Southern Medical University, Guangzhou, China.
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University, Guangzhou, 510515, China.
Br J Pharmacol. 2019 Oct;176(19):3754-3774. doi: 10.1111/bph.14792. Epub 2019 Sep 4.
The pharmacological potential of nanotechnology, especially in drug delivery and bioengineering, has developed rapidly in recent decades. Ion channels, which are easily targeted by external agents, such as nanomaterials (NMs) and synthetic drugs, due to their unique structures, have attracted increasing attention in the fields of nanotechnology and pharmacology for the treatment of ion channel-related diseases. NMs have significant effects on ion channels, and these effects are manifested in many ways, including changes in ion currents, kinetic characteristics and channel distribution. Subsequently, intracellular ion homeostasis, signalling pathways, and intracellular ion stores are affected, leading to the initiation of a range of biological processes. However, the effect of the interactions of NMs with ion channels is an interesting topic that remains obscure. In this review, we have summarized the recent research progress on the direct and indirect interactions between NMs and ion channels and discussed the related molecular mechanisms, which are crucial to the further development of ion channel-related nanotechnological applications.
纳米技术的药理学潜力，特别是在药物输送和生物工程方面，近几十年来发展迅速。由于其独特的结构，离子通道很容易被外部试剂（如纳米材料（NMs）和合成药物）靶向，因此在纳米技术和药理学领域中，它们在治疗与离子通道相关的疾病方面引起了越来越多的关注。NMs 对离子通道有显著的影响，这些影响表现在多个方面，包括离子流、动力学特性和通道分布的变化。随后，细胞内离子稳态、信号通路和细胞内离子储存受到影响，引发了一系列的生物学过程。然而，NMs 与离子通道相互作用的效果是一个有趣的话题，目前仍不清楚。在这篇综述中，我们总结了最近关于 NMs 与离子通道的直接和间接相互作用的研究进展，并讨论了相关的分子机制，这对离子通道相关的纳米技术应用的进一步发展至关重要。
