Pham Vuong M, Matsumura Shinji, Katano Tayo, Funatsu Nobuo, Ito Seiji
Department of Medical Chemistry, Kansai Medical University, Hirakata, Osaka, Japan; Singapore Institute for Neurotechnology (SINAPSE), National University of Singapore, Singapore.
Department of Medical Chemistry, Kansai Medical University, Hirakata, Osaka, Japan.
Neural Regen Res. 2019 Nov;14(11):1870-1879. doi: 10.4103/1673-5374.259603.
Diabetic neuropathy is one of the most serious complications of diabetes, and its increase shows no sign of stopping. Furthermore, current clinical treatments do not yet approach the best effectiveness. Thus, the development of better strategies for treating diabetic neuropathy is an urgent matter. In this review, we first discuss the advantages and disadvantages of some major mouse models of diabetic neuropathy and then address the targets for mechanism-based treatment that have been studied. We also introduce our studies on each part. Using stem cells as a source of neurotrophic factors to target extrinsic factors of diabetic neuropathy, we found that they present a promising treatment.
糖尿病性神经病变是糖尿病最严重的并发症之一，而且其发病率呈持续上升趋势。此外，目前的临床治疗尚未达到最佳疗效。因此，开发更好的糖尿病性神经病变治疗策略迫在眉睫。在本综述中，我们首先讨论了一些主要的糖尿病性神经病变小鼠模型的优缺点，然后阐述了基于机制治疗的研究靶点。我们还介绍了我们在各个方面的研究。利用干细胞作为神经营养因子的来源来针对糖尿病性神经病变的外在因素，我们发现它们是一种很有前景的治疗方法。
