Coelho Zélia Barbosa de Almeida, Mourão Luiza Carvalho, Rodrigues Beatriz Carolina Medeiros, Cardoso-Oliveira Gustavo Pereira, Hincapie Robert, Sanhueza-Chavez Carlos, Finn M G, Fontes Cor Jesus Fernandes, Marques Alexandre Ferreira, Braga Érika Martins
Universidade Federal de Minas Gerais, Departamento de Parasitologia, Belo Horizonte, MG, Brasil.
Georgia Institute of Technology, School of Chemistry and Biochemistry, Atlanta, GA, USA.
Mem Inst Oswaldo Cruz. 2019;114:e190145. doi: 10.1590/0074-02760190145. Epub 2019 Jul 4.
Anti-α-Gal responses may exert a protective effect in falciparum malaria. However, the biological role of such antibodies is still unknown during Plasmodium vivax infections. We investigated IgG and IgM responses to α-Gal in individuals with vivax malaria. Anti-α-Gal IgG and IgM levels were higher in these patients than in controls, but no significant correlation was found between parasitaemia and anti-α-Gal response, nor between this response and ABO blood group status. This is the first study to investigate anti-α-Gal antibodies in P. vivax-infected patients; a larger survey is necessary to achieve a better understanding of host immune response during vivax malaria.
抗α - 半乳糖反应可能在恶性疟原虫疟疾中发挥保护作用。然而，在间日疟原虫感染期间，此类抗体的生物学作用仍不清楚。我们调查了间日疟患者对α - 半乳糖的IgG和IgM反应。这些患者的抗α - 半乳糖IgG和IgM水平高于对照组，但未发现寄生虫血症与抗α - 半乳糖反应之间、以及该反应与ABO血型状态之间存在显著相关性。这是第一项研究间日疟原虫感染患者抗α - 半乳糖抗体的研究；有必要进行更大规模的调查，以更好地了解间日疟期间的宿主免疫反应。
