Dermatololgy, Venereology and Andrology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Plastic surgery Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Int J Dermatol. 2019 Oct;58(10):1212-1222. doi: 10.1111/ijd.14567. Epub 2019 Jul 11.
Scarring is a distressing outcome of acne, as it causes cosmetic and psychological problems to the patients. Unfortunately no single treatment is satisfactory; instead, employing multiple modalities may have better outcome. Autologous adipose tissue-derived adult stem cells (AT-ASCs) and their secretory factors can stimulate collagen synthesis; angiogenesis and migration of fibroblasts thus regenerate damaged tissues. Also, conventional treatments for acne scarring, such as lasers and topical regimens, induce new collagen synthesis via activation of dermal fibroblasts or growth factors. The aim of the study was to verify the effectiveness of AT-ASCs for the treatment of acne scarring vs. the fractional carbon dioxide laser (FxCR).
Split face comparative study included 10 adult patients with post-acne scars on both sides of the face. One side received AT-ASCs single injection while the other received three sessions of FxCR. Scars were then assessed using the global scoring system Goodman and Baron, scar area percent using NIH ImageJ software and functional assessment by measuring the transepidermal water loss (TEWL) and skin hydration. Both sides were followed for three months.
A significant improvement in the degree of scar severity, scar area percent, skin hydration, and TEWL after 3 months of treatment on both sides of the face with insignificant differences between both treatment modalities, provided that AT-ASCs treatment was employed once vs. three sessions of FxCR.
One injection of AT-ASCs is as effective as three sessions of FxCR in the treatment of atrophic acne scars.
疤痕是痤疮的一种令人痛苦的后果，因为它会给患者带来美容和心理问题。不幸的是，没有单一的治疗方法是令人满意的；相反，采用多种方法可能会有更好的效果。自体脂肪组织源性成体干细胞（AT-ASCs）及其分泌因子可以刺激胶原蛋白合成；成纤维细胞的血管生成和迁移从而再生受损组织。此外，痤疮疤痕的传统治疗方法，如激光和局部治疗方案，通过激活真皮成纤维细胞或生长因子来诱导新的胶原蛋白合成。本研究的目的是验证 AT-ASCs 治疗痤疮疤痕的有效性与二氧化碳点阵激光（FxCR）相比。
这项对比研究采用了半脸设计，纳入了 10 名面部两侧均有痤疮后疤痕的成年患者。一侧接受 AT-ASCs 单次注射，另一侧接受三次 FxCR 治疗。然后使用 Goodman 和 Baron 的整体评分系统、NIH ImageJ 软件测量的疤痕面积百分比以及通过测量经表皮水分流失（TEWL）和皮肤水分来评估功能性。两侧均随访 3 个月。
治疗 3 个月后，两侧的疤痕严重程度、疤痕面积百分比、皮肤水分和 TEWL 均有显著改善，两种治疗方法之间无显著差异，但 AT-ASCs 治疗仅需一次，而 FxCR 则需三次。
单次注射 AT-ASCs 与三次 FxCR 治疗凹陷性痤疮疤痕同样有效。
