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一名获得性免疫缺陷综合征患者的导管相关产朊假丝酵母菌菌血症:用分子探针进行菌种鉴定

Catheter-associated Candida utilis fungemia in a patient with acquired immunodeficiency syndrome: species verification with a molecular probe.

作者信息

Alsina A, Mason M, Uphoff R A, Riggsby W S, Becker J M, Murphy D

机构信息

Department of Microbiology, University of Tennessee, Knoxville 37996.

出版信息

J Clin Microbiol. 1988 Apr;26(4):621-4. doi: 10.1128/jcm.26.4.621-624.1988.

Abstract

Candida utilis was cultured from the blood of a patient with acquired immunodeficiency syndrome. The candidemia was apparently associated with catheter implantation. The isolate was identified initially by standard methods and verified by molecular probing. The pattern of actin-specific restriction fragments obtained from the DNA of the isolate, probed with C. albicans actin sequences, corresponded to that of C. utilis. This organism adds to the growing list of Candida species associated with human disease. Molecular probing offers a definitive identification when an unexpected etiological agent is found.

摘要

从一名获得性免疫缺陷综合征患者的血液中培养出了产朊假丝酵母。这种念珠菌血症显然与导管植入有关。最初通过标准方法对分离株进行鉴定,并通过分子探针进行验证。用白色念珠菌肌动蛋白序列探测从该分离株DNA获得的肌动蛋白特异性限制性片段模式,与产朊假丝酵母的模式相符。这种微生物增加了与人类疾病相关的念珠菌种类的名单。当发现意外的病原体时,分子探针提供了一种确定性的鉴定方法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7ffc/266390/f464129f9a85/jcm00076-0028-a.jpg

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